Literature DB >> 9445082

Coadministration of DNA encoding interleukin-6 and hemagglutinin confers protection from influenza virus challenge in mice.

D L Larsen1, N Dybdahl-Sissoko, M W McGregor, R Drape, V Neumann, W F Swain, D P Lunn, C W Olsen.   

Abstract

This study was conducted to investigate whether Accell gene gun coadministration of DNA encoding human interleukin-6 (IL-6) would enhance protective immune responses in mice to an equine influenza A virus hemagglutinin (HA) DNA vaccine. Mice that received HA DNA alone exhibited accelerated clearance of homologous challenge virus but were not protected from infection. In contrast, mice that received both HA and IL-6 DNA had no detectable virus in their lungs after challenge. These results strongly support the use of IL-6 as a cytokine adjuvant in DNA vaccination.

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Year:  1998        PMID： 9445082      PMCID： PMC124660          DOI： 10.1128/JVI.72.2.1704-1708.1998

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  41 in total

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Journal:  Behring Inst Mitt       Date:  1997-02

4.  Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2.

Authors:  Y H Chow; W L Huang; W K Chi; Y D Chu; M H Tao
Journal:  J Virol       Date:  1997-01       Impact factor: 5.103

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Authors:  C W Olsen; M W McGregor; N Dybdahl-Sissoko; B R Schram; K M Nelson; D P Lunn; M D Macklin; W F Swain; V S Hinshaw
Journal:  Vaccine       Date:  1997-07       Impact factor: 3.641

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Authors:  E F Fynan; R G Webster; D H Fuller; J R Haynes; J C Santoro; H L Robinson
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  11 in total

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5.  Protective efficacy of a broadly cross-reactive swine influenza DNA vaccine encoding M2e, cytotoxic T lymphocyte epitope and consensus H3 hemagglutinin.

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7.  Improved lysis efficiency and immunogenicity of Salmonella ghosts mediated by co-expression of λ phage holin-endolysin and ɸX174 gene E.

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8.  Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn.

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9.  The Immune Adjuvant Effects of Flounder (Paralichthys olivaceus) Interleukin-6 on E. tarda Subunit Vaccine OmpV.

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Review 10.  A Review of DNA Vaccines Against Influenza.

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