| Literature DB >> 9445072 |
C Parolin1, A Borsetti, H Choe, M Farzan, P Kolchinsky, M Heesen, Q Ma, C Gerard, G Palú, M E Dorf, T Springer, J Sodroski.
Abstract
The human CXCR-4 molecule serves as a second receptor for primary, T-cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV-1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.Entities:
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Year: 1998 PMID: 9445072 PMCID: PMC124650 DOI: 10.1128/JVI.72.2.1652-1656.1998
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103