Literature DB >> 9444975

Does base composition help predispose the complementarity-determining regions of antibodies to hypermutation?

E A Padlan1.   

Abstract

A survey of the base usage in genes coding for human antibodies reveals that more (A+T) and less (C+G) are found in the segments coding for the complementarity-determining regions, while the opposite is true for the segments coding for framework and constant regions. The possibility that this bias in base usage may contribute to hypermutation is explored.

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Year:  1997        PMID： 9444975     DOI： 10.1016/s0161-5890(97)00074-6

Source DB:  PubMed          Journal:  Mol Immunol        ISSN： 0161-5890            Impact factor:   4.407


  3 in total

1.  Genetic plasticity of V genes under somatic hypermutation: statistical analyses using a new resampling-based methodology.

Authors:  M Oprea; T B Kepler
Journal:  Genome Res       Date:  1999-12       Impact factor: 9.043

2.  Analysis of the expressed heavy chain variable-region genes of Macaca fascicularis and isolation of monoclonal antibodies specific for the Ebola virus' soluble glycoprotein.

Authors:  Chris Druar; Surinder S Saini; Meredith A Cossitt; Fei Yu; Xiangguo Qiu; Thomas W Geisbert; Steven Jones; Peter B Jahrling; Donald I H Stewart; Erik J Wiersma
Journal:  Immunogenetics       Date:  2005-11-08       Impact factor: 2.846

3.  Synthetic antibodies from a four-amino-acid code: a dominant role for tyrosine in antigen recognition.

Authors:  Frederic A Fellouse; Christian Wiesmann; Sachdev S Sidhu
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-11       Impact factor: 11.205
  3 in total

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