Literature DB >> 9443837

Insulin selectively downregulates alpha2-adrenoceptors in the arcuate and dorsomedial nucleus.

B E Levin1, P Israel, D P Lattemann.   

Abstract

Intracerebroventricular infusion of insulin (2 mU/ day) produced selective downregulation of 3H-paraminoclonidine binding to alpha2-adrenoceptors in the hypothalamic arcuate (14%) and dorsomedial (19%) nuclei out of 16 forebrain areas in Wistar rats. Binding of 3H-prazosin to alpha1-adrenoceptors was unaffected. This is in keeping with the known effect of insulin on catecholamine and neuropeptide Y metabolism in these brain regions that play an important role in energy homeostasis.

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Year:  1998        PMID： 9443837     DOI： 10.1016/s0361-9230(97)00336-5

Source DB:  PubMed          Journal:  Brain Res Bull        ISSN： 0361-9230            Impact factor:   4.077


  7 in total

1.  Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling.

Authors:  Christa M Patterson; Sebastien G Bouret; Ambrose A Dunn-Meynell; Barry E Levin
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2009-01-21       Impact factor: 3.619

2.  Agmatine in the hypothalamic paraventricular nucleus stimulates feeding in rats: involvement of neuropeptide Y.

Authors:  B G Taksande; N R Kotagale; K T Nakhate; P D Mali; D M Kokare; K Hirani; N K Subhedar; C T Chopde; R R Ugale
Journal:  Br J Pharmacol       Date:  2011-09       Impact factor: 8.739

3.  Large litter rearing enhances leptin sensitivity and protects selectively bred diet-induced obese rats from becoming obese.

Authors:  Christa M Patterson; Sebastien G Bouret; Sunny Park; Boman G Irani; Ambrose A Dunn-Meynell; Barry E Levin
Journal:  Endocrinology       Date:  2010-07-28       Impact factor: 4.736

Review 4.  Insulin in the brain: sources, localization and functions.

Authors:  Rasoul Ghasemi; Ali Haeri; Leila Dargahi; Zahurin Mohamed; Abolhassan Ahmadiani
Journal:  Mol Neurobiol       Date:  2012-09-07       Impact factor: 5.590

Review 5.  Insulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's disease.

Authors:  Enrique Blázquez; Esther Velázquez; Verónica Hurtado-Carneiro; Juan Miguel Ruiz-Albusac
Journal:  Front Endocrinol (Lausanne)       Date:  2014-10-09       Impact factor: 5.555

6.  Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin.

Authors:  Lars Paeger; Ismene Karakasilioti; Janine Altmüller; Peter Frommolt; Jens Brüning; Peter Kloppenburg
Journal:  Elife       Date:  2017-06-20       Impact factor: 8.140

Review 7.  Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer's disease.

Authors:  Sima Kianpour Rad; Aditya Arya; Hamed Karimian; Priya Madhavan; Farzana Rizwan; Shajan Koshy; Girish Prabhu
Journal:  Drug Des Devel Ther       Date:  2018-11-22       Impact factor: 4.162
  7 in total

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