Literature DB >> 9443606

Localization of two forms of phospholipase C-beta1, a and b, in C6Bu-1 cells.

Y Y Bahk1, H Song, S H Baek, B Y Park, H Kim, S H Ryu, P G Suh.   

Abstract

Phospholipase C-beta1 (PLC-beta1), one of the PLC-beta isozymes, exists as two immunologically distinguishable polypeptides of 150 (PLC-beta1a) and 140 kDa (PLC-beta1b) which are encoded in two distinct transcripts and generated by alternative splicing of a single gene. In this study, the subcellular localization of the two phospholipases C-beta1 proteins was examined in rat C6Bu-1 glioma cells using immunological techniques. Immunoblot analysis revealed that the two forms of PLC-beta1 were detectable in both cytosolic and nuclear fractions. PLC-beta1a appeared to be located preferentially in the cytosol, whereas PLC-beta1b was found predominantly in the nuclei of C6Bu-1 cells. Immunocytochemical experiments confirmed the differential localization of the two PLC-beta1 species in C6Bu-1 cells. These results suggest that the two PLC-beta1 proteins may have different physiological roles in the cell.

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Year:  1998        PMID： 9443606     DOI： 10.1016/s0005-2760(97)00128-8

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


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