Literature DB >> 9443165

Role of pharmacokinetics and metabolism in drug discovery and development.

J H Lin1, A Y Lu.   

Abstract

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Year:  1997        PMID: 9443165

Source DB:  PubMed          Journal:  Pharmacol Rev        ISSN: 0031-6997            Impact factor:   25.468


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  119 in total

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2.  Prediction of blood-brain barrier permeation using quantum chemically derived information.

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3.  Predicting drug pharmacokinetic properties using molecular interaction fields and SIMCA.

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4.  Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes.

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5.  Nano-advantage in enhanced drug delivery with biodegradable nanoparticles: contribution of reduced clearance.

Authors:  Rajendra S Kadam; David W A Bourne; Uday B Kompella
Journal:  Drug Metab Dispos       Date:  2012-04-12       Impact factor: 3.922

Review 6.  ADME of biologics-what have we learned from small molecules?

Authors:  Thomayant Prueksaritanont; Cuyue Tang
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7.  MS(M), an efficient workflow for metabolite identification using hybrid linear ion trap Orbitrap mass spectrometer.

Authors:  Robert Cho; Yingying Huang; Jae C Schwartz; Yan Chen; Timothy J Carlson; Ji Ma
Journal:  J Am Soc Mass Spectrom       Date:  2012-02-14       Impact factor: 3.109

Review 8.  A few specialized issues that should be focused on anti-HIV drug evaluation in vitro.

Authors:  Dao-min Zhuang; Jing-yun Li
Journal:  Virol Sin       Date:  2010-07-28       Impact factor: 4.327

Review 9.  The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery.

Authors:  Dennis A Smith; Li Di; Edward H Kerns
Journal:  Nat Rev Drug Discov       Date:  2010-12       Impact factor: 84.694

10.  Computational approaches for modeling human intestinal absorption and permeability.

Authors:  Govindan Subramanian; Douglas B Kitchen
Journal:  J Mol Model       Date:  2006-04-01       Impact factor: 1.810

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