Literature DB >> 9439509

Are neuronal intranuclear inclusions the common neuropathology of triplet-repeat disorders with polyglutamine-repeat expansions?

S W Davies1, K Beardsall, M Turmaine, M DiFiglia, N Aronin, G P Bates.   

Abstract

Neuronal intranuclear inclusions have been found in the brain of a transgenic mouse model of Huntington's disease and in necropsy brain tissue of patients with Huntington's disease. We suggest that neuronal intranuclear inclusions are the common neuropathology for all inherited diseases caused by expansion of polyglutamine repeats. We also suggest that patients with a pathological diagnosis of neuronal intranuclear hyaline inclusion disease may also have polyglutamine repeat expansions.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9439509     DOI： 10.1016/S0140-6736(97)08360-8

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  24 in total

1.  From neuronal inclusions to neurodegeneration: neuropathological investigation of a transgenic mouse model of Huntington's disease.

Authors:  S W Davies; M Turmaine; B A Cozens; A S Raza; A Mahal; L Mangiarini; G P Bates
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-06-29       Impact factor: 6.237

Review 2.  Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease.

Authors:  J H Cha; A S Frey; S A Alsdorf; J A Kerner; C M Kosinski; L Mangiarini; J B Penney; S W Davies; G P Bates; A B Young
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-06-29       Impact factor: 6.237

3.  Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice.

Authors:  J A Bibb; Z Yan; P Svenningsson; G L Snyder; V A Pieribone; A Horiuchi; A C Nairn; A Messer; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

4.  Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

Authors:  C A Gutekunst; S H Li; H Yi; J S Mulroy; S Kuemmerle; R Jones; D Rye; R J Ferrante; S M Hersch; X J Li
Journal:  J Neurosci       Date:  1999-04-01       Impact factor: 6.167

5.  Neuronal intranuclear inclusions are ultrastructurally and immunologically distinct from cytoplasmic inclusions of neuronal intermediate filament inclusion disease.

Authors:  Sabrina Mosaheb; Julian R Thorpe; Lida Hashemzadeh-Bonehi; Eileen H Bigio; Marla Gearing; Nigel J Cairns
Journal:  Acta Neuropathol       Date:  2005-07-16       Impact factor: 17.088

Review 6.  Aggregation formation in the polyglutamine diseases: protection at a cost?

Authors:  Tiffany W Todd; Janghoo Lim
Journal:  Mol Cells       Date:  2013-06-19       Impact factor: 5.034

7.  Intraneuronal aggregate formation and cell death after viral expression of expanded polyglutamine tracts in the adult rat brain.

Authors:  M C Senut; S T Suhr; B Kaspar; F H Gage
Journal:  J Neurosci       Date:  2000-01-01       Impact factor: 6.167

Review 8.  Huntington's Disease.

Authors:  Steven Finkbeiner
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-06-01       Impact factor: 10.005

9.  SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor.

Authors:  E J Park; D J Schroen; M Yang; H Li; L Li; J D Chen
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

10.  Characterization of intracellular aggregates using fluorescently-tagged polyglutamine-expanded androgen receptor.

Authors:  V Panet-Raymond; B Gottlieb; L K Beitel; H Schipper; M Timiansky; L Pinsky; M A Trifiro
Journal:  Neurotox Res       Date:  2001-07       Impact factor: 3.911
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.