Literature DB >> 9437727

Isolation of relatively large amounts of endomorphin-1 and endomorphin-2 from human brain cortex.

L Hackler1, J E Zadina, L J Ge, A J Kastin.   

Abstract

Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2) were previously isolated from bovine brain. Both peptides showed the greatest selectivity and affinity for the mu opiate receptor of any endogenous substance found to date and may serve as natural ligands for the mu-opiate receptor. We have purified them from the fronto-parietal cortex of human brain tissue by solid phase extraction and high performance liquid chromatography. Peptide content was followed by a specific and sensitive radioimmunoassay with an antibody that was generated against endomorphin-1. The isolated endomorphins showed full biological activity. The tetrapeptides were found in human brain in much higher amounts than in bovine frontal cortex.

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Year:  1997        PMID： 9437727     DOI： 10.1016/s0196-9781(97)00259-3

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  22 in total

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2.  Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues.

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3.  Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue.

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Review 5.  Engineering endomorphin drugs: state of the art.

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Journal:  Expert Opin Ther Pat       Date:  2012-01-04       Impact factor: 6.674

Review 6.  Current research on opioid receptor function.

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7.  Search of the human proteome for endomorphin-1 and endomorphin-2 precursor proteins.

Authors:  Alexandra Terskiy; Kenneth M Wannemacher; Prem N Yadav; Michael Tsai; Bin Tian; Richard D Howells
Journal:  Life Sci       Date:  2007-10-05       Impact factor: 5.037

8.  The spinal antinociceptive effects of endomorphins in rats: behavioral and G protein functional studies.

Authors:  Hong Xie; James H Woods; John R Traynor; Mei-Chuan Ko
Journal:  Anesth Analg       Date:  2008-06       Impact factor: 5.108

9.  Endomorphin 1 and endomorphin 2 suppress in vitro antibody formation at ultra-low concentrations: anti-peptide antibodies but not opioid antagonists block the activity.

Authors:  Benito Anton; Phillipe Leff; Juan C Calva; Rodolfo Acevedo; Alberto Salazar; Maura Matus; Lenin Pavón; Martin Martinez; Joseph J Meissler; Martin W Adler; John P Gaughan; Toby K Eisenstein
Journal:  Brain Behav Immun       Date:  2008-04-18       Impact factor: 7.217

10.  Attenuation of knee joint inflammation by peripherally administered endomorphin-1.

Authors:  Jason J McDougall; Chris L Baker; Petra M Hermann
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