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Literature DB >> 943741

Congenital syphilis after maternal treatment with erythromycin.

Abstract

A case is reported in which erythromycin was used successfully to treat maternal syphilis but failed to adequately treat the fetus. This report and similar studies suggest that oral erythromycin is not a reasonable alternative drug for the treatment of lues in the penicillin-allergic gravid female.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1976 PMID： 943741

Source DB: PubMed Journal: Obstet Gynecol ISSN： 0029-7844 Impact factor: 7.661

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Cited

10 in total

1. A point mutation associated with bacterial macrolide resistance is present in both 23S rRNA genes of an erythromycin-resistant Treponema pallidum clinical isolate.

Authors: L V Stamm; H L Bergen
Journal: Antimicrob Agents Chemother Date: 2000-03 Impact factor: 5.191

Review 2. Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features.

Authors: A E Singh; B Romanowski
Journal: Clin Microbiol Rev Date: 1999-04 Impact factor: 26.132

Review 3. Syphilis in pregnancy.

Authors: M Genç; W J Ledger
Journal: Sex Transm Infect Date: 2000-04 Impact factor: 3.519

4. In vitro culture system to determine MICs and MBCs of antimicrobial agents against Treponema pallidum subsp. pallidum (Nichols strain).

Authors: S J Norris; D G Edmondson
Journal: Antimicrob Agents Chemother Date: 1988-01 Impact factor: 5.191

Congenital syphilis after maternal treatment with erythromycin.

1. A point mutation associated with bacterial macrolide resistance is present in both 23S rRNA genes of an erythromycin-resistant Treponema pallidum clinical isolate.

Review 2. Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features.

Review 3. Syphilis in pregnancy.

4. In vitro culture system to determine MICs and MBCs of antimicrobial agents against Treponema pallidum subsp. pallidum (Nichols strain).

5. Treatment of bacterial infections in pregnancy.

Review 6. Alternative Treatments for Syphilis During Pregnancy.

7. Survival of treponemes after treatment: comments, clinical conclusions, and recommendations.

8. In vitro assay to demonstrate high-level erythromycin resistance of a clinical isolate of Treponema pallidum.

Review 9. Global challenge of antibiotic-resistant Treponema pallidum.

Review 10. Antibiotic resistance in prevalent bacterial and protozoan sexually transmitted infections.