Literature DB >> 9434851

The photogenotoxicity of titanium dioxide particles.

Y Nakagawa1, S Wakuri, K Sakamoto, N Tanaka.   

Abstract

We employed a series of in vitro genotoxicity assays--a single cell gel (SCG) assay with mouse lymphoma L5178Y cells, a microbial mutation assay with Salmonella typhimurium, a mammalian cell mutation assay with L5178Y cells, and a chromosomal aberration assay with Chinese hamster CHL/IU cells--to evaluate the photogenotoxicity of titanium dioxide (TiO2) particles. Without UV/visible light irradiation, TiO2 particles exhibited no or weak genotoxicity. With irradiation, however, TiO2 particles exhibited significant genotoxicity in the SCG and chromosomal aberration assays. Therefore, we concluded that TiO2 particles are photogenotoxic.

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Year:  1997        PMID： 9434851     DOI： 10.1016/s1383-5718(97)00126-5

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  17 in total

1.  Safety assessment of titanium dioxide (E171) as a food additive.

Authors:  Maged Younes; Gabriele Aquilina; Laurence Castle; Karl-Heinz Engel; Paul Fowler; Maria Jose Frutos Fernandez; Peter Fürst; Ursula Gundert-Remy; Rainer Gürtler; Trine Husøy; Melania Manco; Wim Mennes; Peter Moldeus; Sabina Passamonti; Romina Shah; Ine Waalkens-Berendsen; Detlef Wölfle; Emanuela Corsini; Francesco Cubadda; Didima De Groot; Rex FitzGerald; Sara Gunnare; Arno Christian Gutleb; Jan Mast; Alicja Mortensen; Agnes Oomen; Aldert Piersma; Veronika Plichta; Beate Ulbrich; Henk Van Loveren; Diane Benford; Margherita Bignami; Claudia Bolognesi; Riccardo Crebelli; Maria Dusinska; Francesca Marcon; Elsa Nielsen; Josef Schlatter; Christiane Vleminckx; Stefania Barmaz; Maria Carfí; Consuelo Civitella; Alessandra Giarola; Ana Maria Rincon; Rositsa Serafimova; Camilla Smeraldi; Jose Tarazona; Alexandra Tard; Matthew Wright
Journal:  EFSA J       Date:  2021-05-06

2.  Health risk assessments of lithium titanate nanoparticles in rat liver cell model for its safe applications in nanopharmacology and nanomedicine.

Authors:  Hasan Turkez; Erdal Sönmez; Antonio Di Stefano; Yousef I Mokhtar
Journal:  Cytotechnology       Date:  2014-08-23       Impact factor: 2.058

Review 3.  Applications of nanotechnology in dermatology.

Authors:  Lisa A DeLouise
Journal:  J Invest Dermatol       Date:  2012-01-05       Impact factor: 8.551

4.  In vivo demonstration of enhanced radiotherapy using rare earth doped titania nanoparticles.

Authors:  Helen E Townley; Jeewon Kim; Peter J Dobson
Journal:  Nanoscale       Date:  2012-07-06       Impact factor: 7.790

5.  Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signaling.

Authors:  Timothy R Nurkiewicz; Dale W Porter; Ann F Hubbs; Samuel Stone; Bean T Chen; David G Frazer; Matthew A Boegehold; Vincent Castranova
Journal:  Toxicol Sci       Date:  2009-03-06       Impact factor: 4.849

6.  Size of TiO(2) nanoparticles influences their phototoxicity: an in vitro investigation.

Authors:  Sijing Xiong; Saji George; Zhaoxia Ji; Sijie Lin; Haiyang Yu; Robert Damoiseaux; Bryan France; Kee Woei Ng; Say Chye Joachim Loo
Journal:  Arch Toxicol       Date:  2012-08-11       Impact factor: 5.153

7.  Comet assay: a method to evaluate genotoxicity of nano-drug delivery system.

Authors:  Somayeh Vandghanooni; Morteza Eskandani
Journal:  Bioimpacts       Date:  2011-08-06

8.  In vivo skin penetration of quantum dot nanoparticles in the murine model: the effect of UVR.

Authors:  Luke J Mortensen; Gunter Oberdörster; Alice P Pentland; Lisa A Delouise
Journal:  Nano Lett       Date:  2008-08-08       Impact factor: 11.189

9.  Nano-cerium-element-doped titanium dioxide induces apoptosis of Bel 7402 human hepatoma cells in the presence of visible light.

Authors:  Long Wang; Jian Mao; Gao-Hua Zhang; Ming-Jing Tu
Journal:  World J Gastroenterol       Date:  2007-08-07       Impact factor: 5.742

10.  Identification of the mechanisms that drive the toxicity of TiO(2 )particulates: the contribution of physicochemical characteristics.

Authors:  Helinor J Johnston; Gary R Hutchison; Frans M Christensen; Sheona Peters; Steve Hankin; Vicki Stone
Journal:  Part Fibre Toxicol       Date:  2009-12-17       Impact factor: 9.400
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