Literature DB >> 9434609

Acyl-CoA : cholesterol acyltransferase inhibitors from Magnolia obovata.

B M Kwon1, M K Kim, S H Lee, J A Kim, I R Lee, Y K Kim, S H Bok.   

Abstract

In the course of a search for acyl-CoA : cholesterol acyltransferase (ACAT) inhibitors from natural sources, new types of ACAT inhibitors were isolated from the extract of Magnolia obovata leaves, and identified as obovatol, honokiol, and magnolol. The active compounds inhibit rat liver ACAT with IC50 values of 42, 71, and 86 microM, respectively.

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Year:  1997        PMID: 9434609     DOI: 10.1055/s-2006-957762

Source DB:  PubMed          Journal:  Planta Med        ISSN: 0032-0943            Impact factor:   3.352


  3 in total

1.  Obovatol attenuates microglia-mediated neuroinflammation by modulating redox regulation.

Authors:  Jiyeon Ock; Hyung S Han; Su H Hong; So Y Lee; Young-Min Han; Byoung-Mog Kwon; Kyoungho Suk
Journal:  Br J Pharmacol       Date:  2010-04       Impact factor: 8.739

2.  Magnolol attenuates VCAM-1 expression in vitro in TNF-alpha-treated human aortic endothelial cells and in vivo in the aorta of cholesterol-fed rabbits.

Authors:  Yung-Hsiang Chen; Shing-Jong Lin; Jaw-Wen Chen; Hung-Hai Ku; Yuh-Lien Chen
Journal:  Br J Pharmacol       Date:  2002-01       Impact factor: 8.739

3.  Magnolol stimulates steroidogenesis in rat adrenal cells.

Authors:  S M Wang; L J Lee; Y T Huang; J J Chen; Y L Chen
Journal:  Br J Pharmacol       Date:  2000-11       Impact factor: 8.739

  3 in total

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