Literature DB >> 9433807

Influences of immunosuppressive agents, FK506 and cyclosporin on systemic Candida albicans infection in mice.

E Ito1, Y Tanaka.   

Abstract

The effects of the immunosuppressive agents FK506 (tacrolimus) and cyclosporin (CyA) on Candida albicans infection in mice were compared with those of cyclophosphamide. FK506 and CyA did not exacerbate C. albicans infection in mice when the effects were determined on the basis of survival ratio and colony forming units (CFU) in the kidney, although cyclophosphamide (CY) impaired the host defence mechanisms of mice against C. albicans infection. The effects of FK506 and CyA on the body weight of mice, histopathological changes of lymphoid tissues and formation of granulomas in kidney were also studied in comparison with those of CY.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9433807     DOI： 10.1023/a:1006827828838

Source DB:  PubMed          Journal:  Mycopathologia        ISSN： 0301-486X            Impact factor:   2.574


  19 in total

1.  Experimental murine candidiasis: pathological and immune responses in T-lymphocyte-depleted mice.

Authors:  D K Giger; J E Domer; S A Moser; J T McQuitty
Journal:  Infect Immun       Date:  1978-09       Impact factor: 3.441

2.  A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin.

Authors:  J J Siekierka; S H Hung; M Poe; C S Lin; N H Sigal
Journal:  Nature       Date:  1989-10-26       Impact factor: 49.962

3.  Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.

Authors:  J Liu; J D Farmer; W S Lane; J Friedman; I Weissman; S L Schreiber
Journal:  Cell       Date:  1991-08-23       Impact factor: 41.582

4.  Neutrophil depletion increases susceptibility to systemic and vaginal candidiasis in mice, and reveals differences between brain and kidney in mechanisms of host resistance.

Authors:  A Fulurija; R B Ashman; J M Papadimitriou
Journal:  Microbiology       Date:  1996-12       Impact factor: 2.777

5.  Immunosuppressive effect of cyclosporin A on resistance to systemic infection with Candida albicans.

Authors:  A Vecchiarelli; E Cenci; P Marconi; R Rossi; C Riccardi; F Bistoni
Journal:  J Med Microbiol       Date:  1989-11       Impact factor: 2.472

6.  Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity.

Authors:  J Liu; M W Albers; T J Wandless; S Luan; D G Alberg; P J Belshaw; P Cohen; C MacKintosh; C B Klee; S L Schreiber
Journal:  Biochemistry       Date:  1992-04-28       Impact factor: 3.162

7.  Resistance of SCID mice to Candida albicans administered intravenously or colonizing the gut: role of polymorphonuclear leukocytes and macrophages.

Authors:  J Jensen; T Warner; E Balish
Journal:  J Infect Dis       Date:  1993-04       Impact factor: 5.226

8.  Cyclosporin A in cadaveric organ transplantation.

Authors:  R Y Calne; D J White; D B Evans; S Thiru; R G Henderson; D V Hamilton; K Rolles; P McMaster; T J Duffy; B R MacDougall; R Williams
Journal:  Br Med J (Clin Res Ed)       Date:  1981-03-21

9.  Effects of cyclophosphamide on murine candidiasis.

Authors:  S A Moser; J E Domer
Journal:  Infect Immun       Date:  1980-02       Impact factor: 3.441

10.  Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2.

Authors:  D Bunjes; C Hardt; M Röllinghoff; H Wagner
Journal:  Eur J Immunol       Date:  1981-08       Impact factor: 5.532
View more
  2 in total

1.  Treatment of Cyclosporin A retains host defense against invasive pulmonary aspergillosis in a non-immunosuppressive murine model by preserving the myeloid cell population.

Authors:  Sarah Sze Wah Wong; Orhan Rasid; Paris Laskaris; Arnaud Fekkar; Jean-Marc Cavaillon; William J Steinbach; Oumaima Ibrahim-Granet
Journal:  Virulence       Date:  2017-07-06       Impact factor: 5.882

2.  Loss of stem cell regenerative capacity within aged niches.

Authors:  Morgan E Carlson; Irina M Conboy
Journal:  Aging Cell       Date:  2007-03-23       Impact factor: 9.304
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.