Literature DB >> 9433592

Comparison of sib-pair and variance-components methods for genomic screening.

E W Pugh1, C E Jaquish, A J Sorant, J P Doetsch, J E Bailey-Wilson, A F Wilson.   

Abstract

The statistical properties of sib-pair and variance-components linkage methods were compared using the nuclear family data from Problem 2. Overall, the power to detect linkage was not high for either method. The variance-components method had better power for detection of linkage, particularly when covariates were included in the model. Type I error rates were similar to nominal error rates for both methods.

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Year:  1997        PMID: 9433592     DOI: 10.1002/(SICI)1098-2272(1997)14:6<867::AID-GEPI51>3.0.CO;2-K

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN: 0741-0395            Impact factor:   2.135


  8 in total

1.  Assessment of parent-of-origin effects in linkage analysis of quantitative traits.

Authors:  R L Hanson; S Kobes; R S Lindsay; W C Knowler
Journal:  Am J Hum Genet       Date:  2001-03-13       Impact factor: 11.025

2.  Composite statistics for QTL mapping with moderately discordant sibling pairs.

Authors:  W F Forrest; E Feingold
Journal:  Am J Hum Genet       Date:  2000-04-07       Impact factor: 11.025

Review 3.  Quantitative trait linkage studies of diabetes-related traits.

Authors:  Robert L Hanson; William C Knowler
Journal:  Curr Diab Rep       Date:  2003-04       Impact factor: 4.810

4.  Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components.

Authors:  S C Pratt; M J Daly; L Kruglyak
Journal:  Am J Hum Genet       Date:  2000-03       Impact factor: 11.025

5.  A powerful test of parent-of-origin effects for quantitative traits using haplotypes.

Authors:  Rui Feng; Yinghua Wu; Gun Ho Jang; Jose M Ordovas; Donna Arnett
Journal:  PLoS One       Date:  2011-12-13       Impact factor: 3.240

6.  Family-based mapping of quantitative trait loci in plant breeding populations with resistance to Fusarium head blight in wheat as an illustration.

Authors:  U R Rosyara; J L Gonzalez-Hernandez; K D Glover; K R Gedye; J M Stein
Journal:  Theor Appl Genet       Date:  2009-03-26       Impact factor: 5.699

7.  An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians.

Authors:  R L Hanson; M G Ehm; D J Pettitt; M Prochazka; D B Thompson; D Timberlake; T Foroud; S Kobes; L Baier; D K Burns; L Almasy; J Blangero; W T Garvey; P H Bennett; W C Knowler
Journal:  Am J Hum Genet       Date:  1998-10       Impact factor: 11.025

8.  Sex, age and generation effects on genome-wide linkage analysis of gene expression in transformed lymphoblasts.

Authors:  Jagadish Rangrej; Joseph Beyene; Pingzhao Hu; Andrew D Paterson
Journal:  BMC Proc       Date:  2007-12-18
  8 in total

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