Literature DB >> 9433576

Assessing linkage on chromosome 5 using components of variance approach: univariate versus multivariate.

M de Andrade1, T J Thiel, L Yu, C I Amos.   

Abstract

We report results when one disease related quantitative trait (Q1) is analyzed versus multiple related quantitative traits using a components of variance approach [Amos, 1994; de Andrade and Amos, 1996]. In both cases, we used age, sex and environmental factor (EF) as covariates. Analysis with ascertainment correction of samples selected through probands with extremely high trait values was also performed and is presented. Testing procedures to detect linkage using the components of variance approach are discussed. The univariate and multivariate analyses showed effects of locus 15 on chromosome 5 only for Q1. This result was confirmed when using ascertainment correction.

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Year:  1997        PMID： 9433576     DOI： 10.1002/(SICI)1098-2272(1997)14:6<773::AID-GEPI35>3.0.CO;2-L

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN： 0741-0395            Impact factor:   2.135


  10 in total

1.  Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results.

Authors:  J T Williams; P Van Eerdewegh; L Almasy; J Blangero
Journal:  Am J Hum Genet       Date:  1999-10       Impact factor: 11.025

2.  Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure.

Authors:  D B Allison; M C Neale; R Zannolli; N J Schork; C I Amos; J Blangero
Journal:  Am J Hum Genet       Date:  1999-08       Impact factor: 11.025

3.  Composite statistics for QTL mapping with moderately discordant sibling pairs.

Authors:  W F Forrest; E Feingold
Journal:  Am J Hum Genet       Date:  2000-04-07       Impact factor: 11.025

4.  A genomewide linkage scan for quantitative-trait loci for obesity phenotypes.

Authors:  Hong-Wen Deng; Hongyi Deng; Yong-Jun Liu; Yao-Zhong Liu; Fu-Hua Xu; Hui Shen; Theresa Conway; Jin-Long Li; Qing-Yang Huang; K M Davies; Robert R Recker
Journal:  Am J Hum Genet       Date:  2002-03-28       Impact factor: 11.025

5.  Robust estimation of experimentwise P values applied to a genome scan of multiple asthma traits identifies a new region of significant linkage on chromosome 20q13.

Authors:  Manuel A R Ferreira; Louise O'Gorman; Peter Le Souëf; Paul R Burton; Brett G Toelle; Colin F Robertson; Peter M Visscher; Nicholas G Martin; David L Duffy
Journal:  Am J Hum Genet       Date:  2005-10-14       Impact factor: 11.025

6.  Genomic susceptibility Loci for brain atrophy, ventricular volume, and leukoaraiosis in hypertensive sibships.

Authors:  Stephen T Turner; Myriam Fornage; Clifford R Jack; Thomas H Mosley; David S Knopman; Sharon L R Kardia; Eric Boerwinkle; Mariza de Andrade
Journal:  Arch Neurol       Date:  2009-07

7.  Genomic regions that influence plasma levels of inflammatory markers in hypertensive sibships.

Authors:  K Ding; D Feng; M de Andrade; T H Mosley; S T Turner; E Boerwinkle; I J Kullo
Journal:  J Hum Hypertens       Date:  2007-10-25       Impact factor: 3.012

8.  Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: suggestive linkage to 3q13.

Authors:  Alysa E Doyle; Manuel A R Ferreira; Pamela B Sklar; Jessica Lasky-Su; Carter Petty; Steven J Fusillo; Larry J Seidman; Erik G Willcutt; Jordan W Smoller; Shaun Purcell; Joseph Biederman; Stephen V Faraone
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2008-12-05       Impact factor: 3.568

9.  Linkage analysis of obesity phenotypes in pre- and post-menopausal women from a United States mid-western population.

Authors:  Linda E Kelemen; Elizabeth J Atkinson; Mariza de Andrade; V Shane Pankratz; Julie M Cunningham; Alice Wang; Christopher A Hilker; Fergus J Couch; Thomas A Sellers; Celine M Vachon
Journal:  BMC Med Genet       Date:  2010-11-09       Impact factor: 2.103

10.  Localization of genes involved in the metabolic syndrome using multivariate linkage analysis.

Authors:  Curtis Olswold; Mariza de Andrade
Journal:  BMC Genet       Date:  2003-12-31       Impact factor: 2.797
  10 in total

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