Literature DB >> 9433126

Vesicular transport: how many Ypt/Rab-GTPases make a eukaryotic cell?

T Lazar1, M Götte, D Gallwitz.   

Abstract

In eukaryotic cells, protein transport through the secretory and endocytic pathways is mediated by vesicular intermediates. Individual transport steps are regulated by Ras-like guanine nucleotide-binding proteins, termed Ypt in yeast or Rab in mammals. The complete sequencing of the Saccharomyces cerevisiae genome has revealed the total number of Ypt GTPases in this organism. There is some redundancy among the 11 Ypt proteins, and only those involved in the biosynthetic pathway are essential for cell viability.

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Year:  1997        PMID: 9433126     DOI: 10.1016/s0968-0004(97)01150-x

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN: 0968-0004            Impact factor:   13.807


  61 in total

1.  Rab5 induces Rac-independent lamellipodia formation and cell migration.

Authors:  M Spaargaren; J L Bos
Journal:  Mol Biol Cell       Date:  1999-10       Impact factor: 4.138

2.  Sequential action of two GTPases to promote vacuole docking and fusion.

Authors:  G Eitzen; E Will; D Gallwitz; A Haas; W Wickner
Journal:  EMBO J       Date:  2000-12-15       Impact factor: 11.598

3.  A rab1 GTPase is required for transport between the endoplasmic reticulum and golgi apparatus and for normal golgi movement in plants.

Authors:  H Batoko; H Q Zheng; C Hawes; I Moore
Journal:  Plant Cell       Date:  2000-11       Impact factor: 11.277

4.  Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms.

Authors:  A Echard; F J Opdam; H J de Leeuw; F Jollivet; P Savelkoul; W Hendriks; J Voorberg; B Goud; J A Fransen
Journal:  Mol Biol Cell       Date:  2000-11       Impact factor: 4.138

5.  A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion.

Authors:  D F Seals; G Eitzen; N Margolis; W T Wickner; A Price
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-15       Impact factor: 11.205

6.  Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins.

Authors:  A Rak; R Fedorov; K Alexandrov; S Albert; R S Goody; D Gallwitz; A J Scheidig
Journal:  EMBO J       Date:  2000-10-02       Impact factor: 11.598

7.  Yeast rab GTPase-activating protein Gyp1p localizes to the Golgi apparatus and is a negative regulator of Ypt1p.

Authors:  L L Du; P Novick
Journal:  Mol Biol Cell       Date:  2001-05       Impact factor: 4.138

8.  Dual prenylation is required for Rab protein localization and function.

Authors:  Monica Calero; Catherine Z Chen; Wenyan Zhu; Nena Winand; Karyn A Havas; Penny M Gilbert; Christopher G Burd; Ruth N Collins
Journal:  Mol Biol Cell       Date:  2003-02-06       Impact factor: 4.138

9.  Analysis of the small GTPase gene superfamily of Arabidopsis.

Authors:  Vanessa Vernoud; Amy C Horton; Zhenbiao Yang; Erik Nielsen
Journal:  Plant Physiol       Date:  2003-03       Impact factor: 8.340

10.  Specific binding to a novel and essential Golgi membrane protein (Yip1p) functionally links the transport GTPases Ypt1p and Ypt31p.

Authors:  X Yang; H T Matern; D Gallwitz
Journal:  EMBO J       Date:  1998-09-01       Impact factor: 11.598

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