Literature DB >> 9430736

HLA-G polymorphisms: neutral evolution or novel function?

C Ober1, C L Aldrich.   

Abstract

HLA-G is a non-classical class Ib gene with many unusual features. Because of its unique expression pattern, which is primarily limited to fetal cells at the maternal fetal interface, this gene has gained the attention of many investigators. In this paper we review some of the novel features of HLA-G, with particular reference to polymorphic variants in the gene, and discuss the implications of these features for the potential function and evolutionary history of HLA-G.

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Year:  1997        PMID： 9430736     DOI： 10.1016/s0165-0378(97)00062-4

Source DB:  PubMed          Journal:  J Reprod Immunol        ISSN： 0165-0378            Impact factor:   4.054


  11 in total

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4.  HLA-G Expression Pattern: Reliable Assessment for Pregnancy Outcome Prediction.

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6.  HLA-G polymorphisms and soluble HLA-G protein levels in women with recurrent pregnancy loss from Basrah province in Iraq.

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7.  Variation in the HLA-G promoter region influences miscarriage rates.

Authors:  Carole Ober; Carrie L Aldrich; Inna Chervoneva; Christine Billstrand; Fedik Rahimov; Heather L Gray; Terry Hyslop
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8.  Amniotic fluid soluble human leukocyte antigen-G in term and preterm parturition, and intra-amniotic infection/inflammation.

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Review 9.  Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association.

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10.  Analytical approaches to detect maternal/fetal genotype incompatibilities that increase risk of pre-eclampsia.

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