Literature DB >> 9428598

Determination of 5-hydroxy-L-[beta-11C]tryptophan and its in vivo-formed radiolabeled metabolites in brain tissue using high performance liquid chromatography: a study supporting radiotracer kinetics obtained with positron emission tomography.

K J Lindner1, P Hartvig, P Bjurling, K J Fasth, G Westerberg, B Långström.   

Abstract

A high performance liquid chromatographic system was developed for separation of 11C-labeled 5-hydroxy-L-tryptophan ([11C]HTP) and in vivo formed radiolabeled metabolites in rat brain tissue. Analysis of brain homogenate revealed that the main part of the radioactivity was associated with 11C-labeled 5-hydroxyindole-3-acetic acid after intravenous injection of [11C]HTP to the rat. The serotonin synthesis rate in the brain was calculated and closely correlated to the serotonin synthesis rate in monkey and human measured using positron emission tomography.

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Year:  1997        PMID： 9428598     DOI： 10.1016/s0969-8051(97)00114-5

Source DB:  PubMed          Journal:  Nucl Med Biol        ISSN： 0969-8051            Impact factor:   2.408


  4 in total

Review 1.  Measuring serotonin synthesis: from conventional methods to PET tracers and their (pre)clinical implications.

Authors:  Anniek K D Visser; Aren van Waarde; Antoon T M Willemsen; Fokko J Bosker; Paul G M Luiten; Johan A den Boer; Ido P Kema; Rudi A J O Dierckx
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-11-27       Impact factor: 9.236

2.  L-5-hydroxytryptophan resets the circadian locomotor activity rhythm of the nocturnal Indian pygmy field mouse, Mus terricolor.

Authors:  Priyoneel Basu; Muniyandi Singaravel; Chandana Haldar
Journal:  Naturwissenschaften       Date:  2012-02-14

3.  [(11)C]5-HTP and microPET are not suitable for pharmacodynamic studies in the rodent brain.

Authors:  Anniek K D Visser; Nisha K Ramakrishnan; Antoon T M Willemsen; Valentina Di Gialleonardo; Erik F J de Vries; Ido P Kema; Rudi A J O Dierckx; Aren van Waarde
Journal:  J Cereb Blood Flow Metab       Date:  2013-10-02       Impact factor: 6.200

4.  Women with Premenstrual Dysphoria Lack the Seemingly Normal Premenstrual Right-Sided Relative Dominance of 5-HTP-Derived Serotonergic Activity in the Dorsolateral Prefrontal Cortices - A Possible Cause of Disabling Mood Symptoms.

Authors:  Olle Eriksson; Anders Wall; Ulf Olsson; Ina Marteinsdottir; Maria Holstad; Hans Ågren; Per Hartvig; Bengt Långström; Tord Naessén
Journal:  PLoS One       Date:  2016-09-12       Impact factor: 3.240
  4 in total

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