Literature DB >> 9428378

Prognostic value of HLA-DR expression and dendritic cell infiltration in gastric cancer.

S Ishigami1, T Aikou, S Natsugoe, S Hokita, H Iwashige, M Tokushige, S Sonoda.   

Abstract

We attempted to correlate the expression of human leukocyte antigen DR (HLA-DR) and tumor infiltration by S-100-protein-positive dendritic cells with clinicopathologic features in 165 patients with gastric cancer. The expression of HLA-DR was correlated with the histologic type. Infiltration of dendritic cells correlated negatively with distant lymph node metastases, clinical stage, and peritoneal invasion. There was no correlation between the expression of HLA-DR and infiltration by dendritic cells. In patients with resectable gastric cancer, the grade of infiltrating dendritic cells may be a suitable predictor of prognosis.

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Year:  1998        PMID: 9428378     DOI: 10.1159/000011837

Source DB:  PubMed          Journal:  Oncology        ISSN: 0030-2414            Impact factor:   2.935


  17 in total

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