Literature DB >> 9428305

Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury.

S D Lavine1, F M Hofman, B V Zlokovic.   

Abstract

The role of tumor necrosis factor-alpha (TNF alpha) in brain injury is controversial. We studied the effect of anti-TNF-alpha antibody in a rat model of reversible middle cerebral artery occlusion. During focal ischemia and early reperfusion, TNF-alpha was rapidly and transiently released into circulation. Pretreatment with intravenous anti-TNF-alpha antibody reduced cortical (71%, P < 0.015) and subcortical (58%, P < 0.007) injury, enhanced the cerebral blood flow during reperfusion, and improved the neurologic outcome. This further supports the contention that TNF-alpha is a deleterious cytokine in stroke, whereas circulating antibody against TNF-alpha may protect brain from reperfusion injury.

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Year:  1998        PMID： 9428305     DOI： 10.1097/00004647-199801000-00005

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  49 in total

Review 1.  Mechanisms of tumor necrosis factor alpha action on neurodegeneration: interaction with insulin-like growth factor-1.

Authors:  S A Loddick; N J Rothwell
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

2.  Systemic infusions of anti-interleukin-1β neutralizing antibodies reduce short-term brain injury after cerebral ischemia in the ovine fetus.

Authors:  Xiaodi Chen; Virginia Hovanesian; Syed Naqvi; Yow-Pin Lim; Richard Tucker; John E Donahue; Edward G Stopa; Barbara S Stonestreet
Journal:  Brain Behav Immun       Date:  2017-08-02       Impact factor: 7.217

3.  Neutralizing anti-interleukin-1β antibodies reduce ischemia-related interleukin-1β transport across the blood-brain barrier in fetal sheep.

Authors:  Aparna Patra; Xiaodi Chen; Grazyna B Sadowska; Jiyong Zhang; Yow-Pin Lim; James F Padbury; William A Banks; Barbara S Stonestreet
Journal:  Neuroscience       Date:  2017-01-09       Impact factor: 3.590

4.  Opioid receptor activation: suppression of ischemia/reperfusion-induced production of TNF-α in the retina.

Authors:  Shahid Husain; Gregory I Liou; Craig E Crosson
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-04-20       Impact factor: 4.799

5.  Secretory phospholipase A2 IIA is up-regulated by TNF-alpha and IL-1alpha/beta after transient focal cerebral ischemia in rat.

Authors:  Rao Muralikrishna Adibhatla; J F Hatcher
Journal:  Brain Res       Date:  2007-01-03       Impact factor: 3.252

6.  Anti-IL-6 neutralizing antibody modulates blood-brain barrier function in the ovine fetus.

Authors:  Jiyong Zhang; Grazyna B Sadowska; Xiaodi Chen; Seon Yeong Park; Jeong-Eun Kim; Courtney A Bodge; Erin Cummings; Yow-Pin Lim; Oleksandr Makeyev; Walter G Besio; John Gaitanis; William A Banks; Barbara S Stonestreet
Journal:  FASEB J       Date:  2015-01-21       Impact factor: 5.191

Review 7.  Integration of cytokine biology and lipid metabolism in stroke.

Authors:  Rao Muralikrishna Adibhatla; Robert Dempsy; James Franklin Hatcher
Journal:  Front Biosci       Date:  2008-01-01

8.  Evaluation of early macrophage activation and NF-kappaB activity in pulmonary injury caused by deep hypothermia circulatory arrest: an experimental study.

Authors:  Jing-hao Zheng; Bo-tao Gao; Zu-ming Jiang; Xiao-qing Yu; Zhi-wei Xu
Journal:  Pediatr Cardiol       Date:  2009-12-03       Impact factor: 1.655

Review 9.  Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies.

Authors:  Rao Muralikrishna Adibhatla; James F Hatcher
Journal:  CNS Neurol Disord Drug Targets       Date:  2008-06       Impact factor: 4.388

10.  NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats.

Authors:  Hans H Wei; Xi-Chun M Lu; Deborah A Shear; Anu Waghray; Changping Yao; Frank C Tortella; Jitendra R Dave
Journal:  J Neuroinflammation       Date:  2009-08-05       Impact factor: 8.322
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