Literature DB >> 9428164

Mueggelone, a novel inhibitor of fish development from the fresh water cyanobacterium Aphanizomenon flos-aquae.

O Papendorf1, G M König, A D Wright, I Chorus, A Oberemm.   

Abstract

A novel C18 lipid, containing a 10-membered lactone, mueggelone (1), was isolated from a field-collected sample of Aphanizomenon flos-aquae, together with the known compound lupenyl acetate (3). Both structures were secured using extensive spectroscopic analysis (1D and 2D NMR, MS, IR). Biological activity assessment of both compounds indicated them to have significant inhibitory effects on fish embryo larval development.

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Year:  1997        PMID: 9428164     DOI: 10.1021/np970231s

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  5 in total

1.  The zebrafish (Danio rerio) embryo as a model system for identification and characterization of developmental toxins from marine and freshwater microalgae.

Authors:  John P Berry; Miroslav Gantar; Patrick D L Gibbs; Michael C Schmale
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2006-08-10       Impact factor: 3.228

2.  Pharmacology and toxicology of pahayokolide A, a bioactive metabolite from a freshwater species of Lyngbya isolated from the Florida Everglades.

Authors:  John P Berry; Miroslav Gantar; Robert E Gawley; Minglei Wang; Kathleen S Rein
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2004-12       Impact factor: 3.228

3.  Toxicity of cylindrospermopsin, and other apparent metabolites from Cylindrospermopsis raciborskii and Aphanizomenon ovalisporum, to the zebrafish (Danio rerio) embryo.

Authors:  John P Berry; Patrick D L Gibbs; Michael C Schmale; Martin L Saker
Journal:  Toxicon       Date:  2008-12-06       Impact factor: 3.033

4.  Identification of teratogenic polymethoxy-1-alkenes from Cylindrospermopsis raciborskii, and taxonomically diverse freshwater cyanobacteria and green algae.

Authors:  Asha Jaja-Chimedza; Christopher Saez; Kristel Sanchez; Miroslav Gantar; John P Berry
Journal:  Harmful Algae       Date:  2015-11-01       Impact factor: 4.273

5.  Indole alkaloids from Fischerella inhibit vertebrate development in the zebrafish (Danio rerio) embryo model.

Authors:  Katherine Walton; Miroslav Gantar; Patrick D L Gibbs; Michael C Schmale; John P Berry
Journal:  Toxins (Basel)       Date:  2014-12-22       Impact factor: 4.546

  5 in total

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