Literature DB >> 9427090

Behaviour changes in dementia. 1: Point of entry data of a prospective study.

T Hope1, J Keene, K Gedling, S Cooper, C Fairburn, R Jacoby.   

Abstract

OBJECTIVE: This article analyses behaviour changes in dementia at the point of entry to a longitudinal study.
DESIGN: Prospective, longitudinal study of behaviour in dementia, with autopsy follow-up.
SETTING: Subjects with dementia, living at home with a carer. All lived in Oxfordshire, UK. PARTICIPANTS: Ninety-seven people with dementia (Alzheimer's disease and/or vascular dementia) who were living at home with a carer. MEASURES: At 4-monthly intervals, the carers were interviewed and the subjects with dementia were assessed cognitively. Subjects' behaviour was assessed using the Present Behavioural Examination. This is an investigator-based, semi-structured interview consisting of eight main sections covering many different aspects of behaviour. The 121 main questions, with 66 further 'nested' questions, have been shown to have high reliability.
RESULTS: This article analyses the types of behaviour change reported by carers at the point of entry to this long-term study. Few correlations were found between behaviour and age, gender and time since onset of dementia. Some types of behaviour were significantly more prevalent in those with greater cognitive impairment.
CONCLUSIONS: Many of these changes create problems for carers, for example increased aggressive behaviour, wandering, wakefulness at night, incontinence and persecutory ideas. In general, they are more prevalent in people with more severe dementia.

Entities:  

Mesh:

Year:  1997        PMID: 9427090     DOI: 10.1002/(sici)1099-1166(199711)12:11<1062::aid-gps675>3.0.co;2-n

Source DB:  PubMed          Journal:  Int J Geriatr Psychiatry        ISSN: 0885-6230            Impact factor:   3.485


  9 in total

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Authors:  Mitchell K P Lai; Shirley W Tsang; Margaret M Esiri; Paul T Francis; Peter T-H Wong; Christopher P Chen
Journal:  Psychopharmacology (Berl)       Date:  2010-07-13       Impact factor: 4.530

2.  Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer's disease.

Authors:  M K Lai; S W Tsang; J T Alder; J Keene; T Hope; M M Esiri; P T Francis; C P Chen
Journal:  Psychopharmacology (Berl)       Date:  2004-11-18       Impact factor: 4.530

Review 3.  Light therapy and Alzheimer's disease and related dementia: past, present, and future.

Authors:  Nicholas Hanford; Mariana Figueiro
Journal:  J Alzheimers Dis       Date:  2013       Impact factor: 4.472

4.  Characterization of histamine H3 receptors in Alzheimer's Disease brain and amyloid over-expressing TASTPM mice.

Authors:  A D Medhurst; J C Roberts; J Lee; C P L-H Chen; S H Brown; S Roman; M K P Lai
Journal:  Br J Pharmacol       Date:  2009-02-16       Impact factor: 8.739

5.  Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology.

Authors:  Mitchell K P Lai; Michelle G K Tan; Sara Kirvell; Carl Hobbs; Jasinda Lee; Margaret M Esiri; Christopher P Chen; Paul T Francis
Journal:  J Neural Transm (Vienna)       Date:  2008-05-28       Impact factor: 3.575

6.  Loss of [3H]4-DAMP binding to muscarinic receptors in the orbitofrontal cortex of Alzheimer's disease patients with psychosis.

Authors:  S W Y Tsang; P T Francis; M M Esiri; P T H Wong; C P L H Chen; M K P Lai
Journal:  Psychopharmacology (Berl)       Date:  2008-03-30       Impact factor: 4.530

7.  Exploration of verbal repetition in people with dementia using an online symptom-tracking tool.

Authors:  Emily Reeve; Pierre Molin; Amaris Hui; Kenneth Rockwood
Journal:  Int Psychogeriatr       Date:  2017-03-09       Impact factor: 3.878

8.  Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimer's disease patients.

Authors:  Jasinda H Lee; Shu Qing Koh; Simone Guadagna; Paul T Francis; Margaret M Esiri; Christopher P Chen; Peter T-H Wong; Gavin S Dawe; Mitchell K P Lai
Journal:  Psychopharmacology (Berl)       Date:  2015-11-06       Impact factor: 4.530

9.  Neuropsychiatric Inventory data in a Belgian sample of elderly persons with and without dementia.

Authors:  Gilles P Squelard; Pierre A Missotten; Louis Paquay; Jan De Lepeleire; Frank J V M Buntinx; Ovide Fontaine; Stephane R Adam; Michel J D Ylieff
Journal:  Clin Interv Aging       Date:  2012-10-17       Impact factor: 4.458

  9 in total

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