| Literature DB >> 9426003 |
C A Driessen1, H J Winkens, L D Kuhlmann, B P Janssen, A H van Vugt, A F Deutman, J J Janssen.
Abstract
We recently cloned the murine 11-cis retinol dehydrogenase gene. A second gene, the murine GCN5L1 gene, was found to be situated upstream of the murine 11-cis retinol dehydrogenase gene. We have isolated and sequenced the complete coding sequence of the murine GCN5L1 gene. The distance between the 3'-end of the murine GCN5L1 gene and the 5'-end of the 11-cis retinol dehydrogenase gene is only 776 nt. The murine GCNSL1 gene consists of four exons encompassing approximately 3.5 kb of genomic DNA. Intron/exon splice sites conform to the GT/AG rule. The open reading frame consists of 375 nucleotides encoding a 14 kDa protein. The murine GCN5L1, like the human GCN5L1 protein, displays weak homology (27%) to yeast GCN5. The distance between the murine, human and bovine GCN5L1 and 11-cis retinol dehydrogenase genes appeared to be conserved.Entities:
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Year: 1997 PMID： 9426003 DOI： 10.1016/s0378-1119(97)00486-1
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688