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Literature DB >> 9425733

Is CTLA-4 a negative regulator for T-cell activation?

Abstract

Immune responses can be a two-sided sword: although lack of immunity can be fatal, so can over-activation of the immune system. The concept of homeostatic balance in immune regulation has consequently been at the core of immune research. In this context, Yang Liu takes a cautious view of the concept that CTLA-4 is a negative regulator of T-cell activation.

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Year: 1997 PMID： 9425733 DOI： 10.1016/s0167-5699(97)01170-5

Source DB: PubMed Journal: Immunol Today ISSN： 0167-5699

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Cited

13 in total

Review 1. CD28, CTLA-4 and their ligands: who does what and to whom?

Authors: D M Sansom
Journal: Immunology Date: 2000-10 Impact factor: 7.397

2. A VISTA on PD-1H.

Authors: Yang Liu
Journal: J Clin Invest Date: 2014-04-17 Impact factor: 14.808

3. B7-CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge.

Authors: P Zheng; Y Wu; Y Guo; C Lee; Y Liu
Journal: Proc Natl Acad Sci U S A Date: 1998-05-26 Impact factor: 11.205

Review 4. Mechanisms and assessment of lectin-mediated mitogenesis.

Authors: D C Kilpatrick
Journal: Mol Biotechnol Date: 1999-02 Impact factor: 2.695

5. Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity.

Authors: Jens Eberlein; Bennett Davenport; Tom T Nguyen; Francisco Victorino; Tim Sparwasser; Dirk Homann
Journal: J Virol Date: 2011-12-07 Impact factor: 5.103

6. Interleukin-4-independent acceleration of cutaneous leishmaniasis in susceptible BALB/c mice following treatment with anti-CTLA4 antibody.

Authors: F P Heinzel; R A Maier
Journal: Infect Immun Date: 1999-12 Impact factor: 3.441

Is CTLA-4 a negative regulator for T-cell activation?

Review 1. CD28, CTLA-4 and their ligands: who does what and to whom?

2. A VISTA on PD-1H.

3. B7-CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge.

Review 4. Mechanisms and assessment of lectin-mediated mitogenesis.

5. Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity.

6. Interleukin-4-independent acceleration of cutaneous leishmaniasis in susceptible BALB/c mice following treatment with anti-CTLA4 antibody.

7. Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.

Review 8. Role of the CTLA-4 receptor in T cell activation and immunity. Physiologic function of the CTLA-4 receptor.

9. Expression of CTLA-4 molecule in peripheral blood T lymphocytes from patients with systemic lupus erythematosus.

Review 10. Preserving the CTLA-4 Checkpoint for Safer and More Effective Cancer Immunotherapy.