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Literature DB >> 942399

The mechanism of the inhibition of the mitochondrial pyruvate transportater by alpha-cyanocinnamate derivatives.

Abstract

Pyruvate transport into rat liver mitochondria is inhibited by a variety of thiol reagents. alpha-Cyanocinnamate and its derivates, potent and reversible inhibitors of pyruvate transport, react reversibly with mercaptoethanol and cysteine to form addition products. It is concluded that these inhibitors react with an essential thiol group on the pyruvate carrier.

Entities: Chemical Species

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Year: 1976 PMID： 942399 PMCID： PMC1163730 DOI： 10.1042/bj1560181

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

6 in total

1. The transport of pyruvate in rat liver mitochondria.

Authors: S Papa; A Francavilla; G Paradies; B Meduri
Journal: FEBS Lett Date: 1971-01-30 Impact factor: 4.124

2. The transport of monocarboxylic oxoacids in rat liver mitochondria.

Authors: G Paradies; S Papa
Journal: FEBS Lett Date: 1975-03-15 Impact factor: 4.124

3. On the mechanism of translocation of pyruvate and other monocarboxylic acids in rat-liver mitochondria.

Authors: S Papa; G Paradies
Journal: Eur J Biochem Date: 1974-11-01

4. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors.

Authors: A P Halestrap
Journal: Biochem J Date: 1975-04 Impact factor: 3.857

5. The specificity and metabolic implications of the inhibition of pyruvate transport in isolated mitochondria and intact tissue preparations by alpha-Cyano-4-hydroxycinnamate and related compounds.

Authors: A P Halestrap; R M Denton
Journal: Biochem J Date: 1975-04 Impact factor: 3.857

6. Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate.

Authors: A P Halestrap; R M Denton
Journal: Biochem J Date: 1974-02 Impact factor: 3.857

6 in total

30 in total

1. Vibrational analysis of α-cyanohydroxycinnamic acid.

Authors: Elmer-Rico E Mojica; Jayson Vedad; Ruel Z B Desamero
Journal: J Mol Struct Date: 2015-08-15 Impact factor: 3.196

2. Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.

Authors: Chendong Yang; Bookyung Ko; Christopher T Hensley; Lei Jiang; Ajla T Wasti; Jiyeon Kim; Jessica Sudderth; Maria Antonietta Calvaruso; Lloyd Lumata; Matthew Mitsche; Jared Rutter; Matthew E Merritt; Ralph J DeBerardinis
Journal: Mol Cell Date: 2014-10-21 Impact factor: 17.970

3. Purification of aldehyde dehydrogenase from rat liver mitochondria by alpha-cyanocinnamate affinity chromatography.

Authors: R C Poole; A P Halestrap
Journal: Biochem J Date: 1989-04-01 Impact factor: 3.857

4. Pyruvate and ketone-body transport across the mitochondrial membrane. Exchange properties, pH-dependence and mechanism of the carrier.

Authors: A P Halestrap
Journal: Biochem J Date: 1978-06-15 Impact factor: 3.857

5. Stimulation of pyruvate transport in metabolizing mitochondria through changes in the transmembrane pH gradient induced by glucagon treatment of rats.

Authors: A P Halestrap
Journal: Biochem J Date: 1978-06-15 Impact factor: 3.857

6. Effect of alloxan on the transport of dicarboxylate, tricarboxylate, pyruvate and glutamate in isolated mouse liver mitochondria.

Authors: L Nelson; L Boquist
Journal: Acta Diabetol Lat Date: 1982 Jul-Sep

10. The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications.

Authors: E A Wiemer; P A Michels; F R Opperdoes
Journal: Biochem J Date: 1995-12-01 Impact factor: 3.857