Literature DB >> 9423888

Capsular polysaccharide-fimbrial protein conjugate vaccine protects against Porphyromonas gingivalis infection in SCID mice reconstituted with human peripheral blood lymphocytes.

J I Choi1, R E Schifferle, F Yoshimura, B W Kim.   

Abstract

The effect of immunization with either a Porphyromonas gingivalis fimbrial protein, a capsular polysaccharide, or a capsular polysaccharide-fimbrial protein conjugate vaccine were compared in hu-PBL-SCID mice. A significantly higher human immunoglobulin G antibody response and the highest degree of in vivo protection against bacterial challenge was observed in the group immunized with the conjugate vaccine. It was concluded that capsular polysaccharide-fimbrial protein conjugate from P. gingivalis could potentially be developed as a vaccine against periodontal infection by P. gingivalis.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9423888      PMCID： PMC107916     

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  13 in total

1.  Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency.

Authors:  W Schuler; I J Weiler; A Schuler; R A Phillips; N Rosenberg; T W Mak; J F Kearney; R P Perry; M J Bosma
Journal:  Cell       Date:  1986-09-26       Impact factor: 41.582

2.  Immunoglobulin allotypes and immunoglobulin G subclass responses to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in early-onset periodontitis.

Authors:  J I Choi; M H Ha; J H Kim; S J Kim
Journal:  Infect Immun       Date:  1996-10       Impact factor: 3.441

3.  Antibody responses to Haemophilus influenzae type b polysaccharide vaccine in relation to Km(1) and G2m(23) immunoglobulin allotypes.

Authors:  D M Granoff; P G Shackelford; J P Pandey; E G Boies
Journal:  J Infect Dis       Date:  1986-08       Impact factor: 5.226

Review 4.  The humoral response in patients with periodontitis: effects of treatment and prospects for a vaccine.

Authors:  R C Page
Journal:  Compend Suppl       Date:  1994

5.  Genes associated with the G2m(23) immunoglobulin allotype regulate the IgG subclass responses to Haemophilus influenzae type b polysaccharide vaccine.

Authors:  D M Granoff; B K Suarez; J P Pandey; P G Shackelford
Journal:  J Infect Dis       Date:  1988-06       Impact factor: 5.226

6.  Immunization with Porphyromonas (Bacteroides) gingivalis fimbriae protects against periodontal destruction.

Authors:  R T Evans; B Klausen; H T Sojar; G S Bedi; C Sfintescu; N S Ramamurthy; L M Golub; R J Genco
Journal:  Infect Immun       Date:  1992-07       Impact factor: 3.441

7.  A severe combined immunodeficiency mutation in the mouse.

Authors:  G C Bosma; R P Custer; M J Bosma
Journal:  Nature       Date:  1983-02-10       Impact factor: 49.962

8.  Purification and characterization of a novel type of fimbriae from the oral anaerobe Bacteroides gingivalis.

Authors:  F Yoshimura; K Takahashi; Y Nodasaka; T Suzuki
Journal:  J Bacteriol       Date:  1984-12       Impact factor: 3.490

9.  Correlation between G2m(n) immunoglobulin allotype and human antibody response and susceptibility to polysaccharide encapsulated bacteria.

Authors:  D M Ambrosino; G Schiffman; E C Gotschlich; P H Schur; G A Rosenberg; G G DeLange; E van Loghem; G R Siber
Journal:  J Clin Invest       Date:  1985-06       Impact factor: 14.808

10.  Modification of experimental Porphyromonas gingivalis murine infection by immunization with a polysaccharide-protein conjugate.

Authors:  R E Schifferle; P B Chen; L B Davern; A Aguirre; R J Genco; M J Levine
Journal:  Oral Microbiol Immunol       Date:  1993-10
View more
  6 in total

1.  Alpha C protein as a carrier for type III capsular polysaccharide and as a protective protein in group B streptococcal vaccines.

Authors:  C Gravekamp; D L Kasper; L C Paoletti; L C Madoff
Journal:  Infect Immun       Date:  1999-05       Impact factor: 3.441

2.  The K1 serotype capsular polysaccharide of Porphyromonas gingivalis elicits chemokine production from murine macrophages that facilitates cell migration.

Authors:  Gabriela d'Empaire; Michael T Baer; Frank C Gibson
Journal:  Infect Immun       Date:  2006-08-28       Impact factor: 3.441

Review 3.  The use of rodent models to investigate host-bacteria interactions related to periodontal diseases.

Authors:  Dana T Graves; Daniel Fine; Yen-Tung A Teng; Thomas E Van Dyke; George Hajishengallis
Journal:  J Clin Periodontol       Date:  2008-02       Impact factor: 8.728

4.  Immunization with Porphyromonas gingivalis capsular polysaccharide prevents P. gingivalis-elicited oral bone loss in a murine model.

Authors:  Dario Gonzalez; Arthur O Tzianabos; Caroline A Genco; Frank C Gibson
Journal:  Infect Immun       Date:  2003-04       Impact factor: 3.441

5.  Vaccines against periodontitis: a forward-looking review.

Authors:  Jeom-Il Choi; Gregory J Seymour
Journal:  J Periodontal Implant Sci       Date:  2010-08-30       Impact factor: 2.614

6.  A Porphyromonas gingivalis Capsule-Conjugate Vaccine Protects From Experimental Oral Bone Loss.

Authors:  Fernanda G Rocha; Aym Berges; Angie Sedra; Shirin Ghods; Neeraj Kapoor; Lucy Pill; Mary Ellen Davey; Jeff Fairman; Frank C Gibson
Journal:  Front Oral Health       Date:  2021-07-05
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.