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Literature DB >> 942387

Isolation of the liver N-aspartyl-beta-glucosaminidase in aspartylglucosaminuria.

Abstract

The isolation of liver N-aspartyl-beta-glucosaminidase in human aspartylglucosaminuria, where this enzyme activity is diminished, yields an enzyme molecule with the same molecular weight and pH optimum as the normal enzyme. Its activity is 10% of that of the control preparation. Combination of both enzymes results in the summation of both activities, and the pathological enzyme does not inhibit the control preparation. It is concluded that no change into a totally different isoenzyme has occurred in aspartylglucosaminuria.

Entities: Disease Species

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Year: 1976 PMID： 942387 PMCID： PMC1172648 DOI： 10.1042/bj1530749

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

8 in total

1. Studies on N-aspartyl-beta-glucosaminidase in aspartylglycosaminuria.

Authors: H Somer; J Palo; H Savolainen; A Konttinen
Journal: Clin Chim Acta Date: 1975-04-16 Impact factor: 3.786

2. Estimation of molecular weights of small proteins on polyacrylamide gel electrophoresis.

Authors: A Gonenne; J Lebowitz
Journal: Anal Biochem Date: 1975-04 Impact factor: 3.365

3. DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

Authors: B J DAVIS
Journal: Ann N Y Acad Sci Date: 1964-12-28 Impact factor: 5.691

4. A modified colorimetric method for the estimation of N-acetylamino sugars.

Authors: J L REISSIG; J L STORMINGER; L F LELOIR
Journal: J Biol Chem Date: 1955-12 Impact factor: 5.157

5. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

6. Aspartylglycosaminuria. An inborn error of metabolism associated with mental defect.

Authors: R J Pollitt; F A Jenner; H Merskey
Journal: Lancet Date: 1968-08-03 Impact factor: 79.321

7. Glycoasparagine metabolites in patients with aspartylglycosaminuria: comparison between English and Finnish patients with special reference to storage materials.

Authors: J Palo; R J Pollitt; K M Pretty; H Savolainen
Journal: Clin Chim Acta Date: 1973-08-17 Impact factor: 3.786

8. Distribution, purification and properties of 1-aspartamido-beta-N-acetylglucosamine amidohydrolase.

Authors: J Conchie; I Strachan
Journal: Biochem J Date: 1969-12 Impact factor: 3.857

8 in total

4 in total

Isolation of the liver N-aspartyl-beta-glucosaminidase in aspartylglucosaminuria.

1. Studies on N-aspartyl-beta-glucosaminidase in aspartylglycosaminuria.

2. Estimation of molecular weights of small proteins on polyacrylamide gel electrophoresis.

3. DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

4. A modified colorimetric method for the estimation of N-acetylamino sugars.

5. Protein measurement with the Folin phenol reagent.

6. Aspartylglycosaminuria. An inborn error of metabolism associated with mental defect.

7. Glycoasparagine metabolites in patients with aspartylglycosaminuria: comparison between English and Finnish patients with special reference to storage materials.

8. Distribution, purification and properties of 1-aspartamido-beta-N-acetylglucosamine amidohydrolase.

1. Purification and some properties of 1-aspartamido-beta-N-acetylglucosamine amidohydrolase from human liver.

2. Isolation of a human hepatic 60 kDa aspartylglucosaminidase consisting of three non-identical polypeptides.

Review 3. Aspartylglycosaminuria: an inborn error of glycoprotein catabolism.

4. Purification and structure of human liver aspartylglucosaminidase.