Performance of modified cyanoacrylate composition as tissue adhesives for soft and hard tissues.

A suspected absorbable cyanoacrylate, methoxypropyl cyanoacrylate (MPC), was investigated as a component of a new modified cyanoacrylate system. Reactive modifiers based on absorbable polymeric oxalates, which act as plasticizers as well as thickening agents, were incorporated into this system. It was found that the MPC with an oxalate modifier resulted in a higher adhesive strength than isobutyl cyanoacrylate (IBC) when used to approximate soft tissue. However, the IBC was superior in hard tissue applications. This coincides with the conclusion that modulus matching of the adhesive and substrate is a key contributor to joint strength.