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Literature DB >> 9421526

Human RPA (hSSB) interacts with EBNA1, the latent origin binding protein of Epstein-Barr virus.

D Zhang¹, L Frappier, E Gibbs, J Hurwitz, M O'Donnell.

Abstract

RPA is the replicative single-strand DNA (ssDNA) binding protein of eukaryotic chromosomes. This report shows that human RPA interacts with EBNA1, the latent origin binding protein of Epstein-Barr virus (EBV). RPA binds to EBNA1 both in solution, and when EBNA1 is bound to the EBV origin. RPA is a heterotrimer, and the main contact with EBNA1 is formed through the 70 kDa subunit of RPA, the subunit which binds to ssDNA. We propose that this interaction between RPA and EBNA1 is an early step in activation of the latent origin of EBV.

Entities: Gene Species

Mesh：

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Year: 1998 PMID： 9421526 PMCID： PMC147273 DOI： 10.1093/nar/26.2.631

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

38 in total

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23 in total

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Authors: Sibille Humme; Gilbert Reisbach; Regina Feederle; Henri-Jacques Delecluse; Kristine Bousset; Wolfgang Hammerschmidt; Aloys Schepers
Journal: Proc Natl Acad Sci U S A Date: 2003-08-28 Impact factor: 11.205