Literature DB >> 9421253

Anticonvulsant properties of gamma-decanolactone in mice.

G P Coelho de Souza1, E Elisabetsky, D S Nunes, S K Rabelo, M Nascimento da Silva.   

Abstract

Lactones have been proven to be bioactive. We have shown that compounds present in the essential oil from Aeollanthus suaveolens, used as an anticonvulsant in the Brazilian Amazon, has sedative properties. This paper reports on the evaluation of the systemic administration of gamma-decanolactone, structurally related to lactones present in the essential oil of A. suaveolens, on mice experimental models useful for detecting psychopharmacological activity. The results show that gamma-decanolactone has dose-dependent marked effects on the central nervous system, including hypnotic, anticonvulsant and hypothermic activity. The effects of gamma-decanolactone revealed by this evaluation point to the validity of exploring lactones as sources of new anticonvulsant agents.

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Year:  1997        PMID： 9421253     DOI： 10.1016/s0378-8741(97)00102-5

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  3 in total

1.  Gamma-Decanolactone Alters the Expression of GluN2B, A1 Receptors, and COX-2 and Reduces DNA Damage in the PTZ-Induced Seizure Model After Subchronic Treatment in Mice.

Authors:  Fernanda Marcelia Dos Santos; Pricila Fernandes Pflüger; Leticia Lazzarotto; Mariana Uczay; Wesley Roberto de Aguida; Lisiane Santos da Silva; Fernanda Brião Menezes Boaretto; Jayne Torres de Sousa; Jaqueline Nascimento Picada; Iraci Lucena da Silva Torres; Patrícia Pereira
Journal:  Neurochem Res       Date:  2021-05-21       Impact factor: 3.996

2.  Effects of gamma-decanolactone on seizures induced by PTZ-kindling in mice.

Authors:  Paulo Alexandre de Oliveira; Felipe Luis Lino; Shandale Emanuele Cappelari; Lucimar Filot da Silva Brum; Jaqueline Nascimento Picada; Patrícia Pereira
Journal:  Exp Brain Res       Date:  2008-02-05       Impact factor: 1.972

Review 3.  Essential oils and their constituents: anticonvulsant activity.

Authors:  Reinaldo Nóbrega de Almeida; Maria de Fátima Agra; Flávia Negromonte Souto Maior; Damião Pergentino de Sousa
Journal:  Molecules       Date:  2011-03-23       Impact factor: 4.411
  3 in total

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