Literature DB >> 9420699

Experimental and clinical experience with iodine 123-labeled iodophenylpentadecanoic acid in cardiology.

S N Reske1.   

Abstract

Iodine 123-labeled iodophenylpentadecanoic acid (IPPA) has been synthesized for investigating myocardial free fatty acid (FFA) metabolism. The diagnostic application of labeled FFA in heart disease may be important, because FFA is the preferred substrate of cardiac energy metabolism at rest in the fasting state. In addition, regional myocardial FFA uptake and regional myocardial blood flow are tightly coupled in normal myocardium with beta-oxidation, which is extremely sensitive to oxygen deprivation. This article outlines basic physiologic pathways of cardiac IPPA metabolism in normal, acutely ischemic, and reperfused viable myocardium and summarizes the results of experimental studies in animals, validating the application of IPPA as an 123I-labeled fatty acid analog. In addition, the most important clinical studies indicating the clinical use of IPPA for diagnosis of coronary heart disease and myocardial viability are presented.

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Year:  1994        PMID： 9420699     DOI： 10.1007/bf02940070

Source DB:  PubMed          Journal:  J Nucl Cardiol        ISSN： 1071-3581            Impact factor:   5.952


  21 in total

1.  [Reduced myocardial fatty acid utilization in coronary heart disease following symptom limited ergometric stress. Detection of pathologic metabolic patterns using iodine-123-phenylpentadecanoic acid and sequential SPECT].

Authors:  S N Reske; J Nitsch; E von der Lohe; H J Simon; P Bardos; U Büll
Journal:  Z Kardiol       Date:  1989-04

2.  The intramyocardial fate of [1-14C] palmitate, iodopalmitate and iodophenylpentadecanoate in isolated rat hearts. A contribution to the choice of an iodinated fatty acid as a tracer of myocardial metabolism.

Authors:  C M Keriel; T G Humbert; C R Berard; D S Marti Batlle; D Le Bars; J P Mathieu; C Luu-Duc; M Comet; P J Cuchet
Journal:  J Mol Cell Cardiol       Date:  1990-12       Impact factor: 5.000

3.  Iodophenylpentadecanoic acid-myocardial blood flow relationship during maximal exercise with coronary occlusion.

Authors:  J H Caldwell; G V Martin; J M Link; K A Krohn; J B Bassingthwaighte
Journal:  J Nucl Med       Date:  1990-01       Impact factor: 10.057

4.  Iodine-123 phenylpentadecanoic acid: detection of acute myocardial infarction and injury in dogs using an iodinated fatty acid and single-photon emission tomography.

Authors:  J S Rellas; J R Corbett; P Kulkarni; C Morgan; M D Devous; L M Buja; L Bush; R W Parkey; J T Willerson; S E Lewis
Journal:  Am J Cardiol       Date:  1983-12-01       Impact factor: 2.778

5.  Evaluation of myocardial viability with technetium-99m hexakis-2-methoxyisobutyl isonitrile and iodine-123 phenylpentadecanoic acid and single photon emission tomography.

Authors:  J T Kuikka; H Mussalo; S Hietakorpi; E Vanninen; E Länsimies
Journal:  Eur J Nucl Med       Date:  1992

6.  Single photon emission tomography imaging of myocardial oxidative metabolism with 15-(p-[123I]iodophenyl) pentadecanoic acid in patients with coronary artery disease and aorto-coronary bypass graft surgery.

Authors:  J Kropp; J Likungu; P G Kirchhoff; F F Knapp; K Reichmann; S N Reske; H J Biersack
Journal:  Eur J Nucl Med       Date:  1991

7.  Metabolism of 15 (p 123I iodophenyl-)pentadecanoic acid in heart muscle and noncardiac tissues.

Authors:  S N Reske; W Sauer; H J Machulla; J Knust; C Winkler
Journal:  Eur J Nucl Med       Date:  1985

8.  Effect of myocardial perfusion and metabolic interventions on cardiac kinetics of phenylpentadecanoic acid (IPPA) I 123.

Authors:  S N Reske; S Schön; W Schmitt; H J Machulla; R Knopp; C Winkler
Journal:  Eur J Nucl Med       Date:  1986

9.  15(p-[123I]Iodophenyl)pentadecanoic acid as tracer of lipid metabolism: comparison with [1-14C]palmitic acid in murine tissues.

Authors:  S N Reske; W Sauer; H J Machulla; C Winkler
Journal:  J Nucl Med       Date:  1984-12       Impact factor: 10.057

10.  123I-phenylpentadecanoic acid as a tracer of cardiac free fatty acid metabolism. Experimental and clinical results.

Authors:  S N Reske
Journal:  Eur Heart J       Date:  1985-08       Impact factor: 29.983
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  2 in total

Review 1.  Imaging of myocardial fatty acid oxidation.

Authors:  Kieren J Mather; Timothy R DeGrado
Journal:  Biochim Biophys Acta       Date:  2016-02-27

Review 2.  Cardiac metabolism: a technical spectrum of modalities including positron emission tomography, single-photon emission computed tomography, and magnetic resonance spectroscopy.

Authors:  R Valkema; B L van Eck-Smit; E E van der Wall
Journal:  J Nucl Cardiol       Date:  1994 Nov-Dec       Impact factor: 5.952
  2 in total

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