| Literature DB >> 9420284 |
J A Beatty1, J J Callanan, A Terry, O Jarrett, J C Neil.
Abstract
We describe the histopathological, immunohistochemical, and molecular characterization of a lymphoma arising in a 7-year-old cat following experimental infection with feline immunodeficiency virus (FIV). The tumor was high grade and of B-cell lineage. The transformed cell had an immature phenotype (CD79a+, CD79b-, CD21-, immunoglobulin heavy and light chain negative), confirmed by antigen receptor gene analysis, which showed germ line configuration. Single-copy, clonally integrated FIV provirus was detected in tumor genomic DNA. FIV p24 antigen was not detected in tumor cells by immunostaining. This study provides the first evidence that the feline lentivirus may play a direct role in cell transformation under certain circumstances.Entities:
Mesh：
Substances：
Year: 1998 PMID： 9420284 PMCID： PMC109433 DOI： 10.1128/JVI.72.1.767-771.1998
Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103