Literature DB >> 9420055

Mutations at codon 184 in simian immunodeficiency virus reverse transcriptase confer resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine.

E Cherry1, M Slater, H Salomon, E Rud, M A Wainberg.   

Abstract

Variants of simian immunodeficiency virus (SIV) that display greater than 2,000-fold resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine (3TC) were generated through in vitro passage and drug selection. The polymerase regions of several of these resistant viruses were sequenced and were found to share either of two codon alterations at site 184 in reverse transcriptase (ATG to ATA [methionine to isoleucine] and ATG to GTA [methionine to valine]). The biological relevance of these substitutions for 3TC was confirmed by site-directed mutagenesis with the SIVmac239 infectious recombinant clone of SIV.

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Year:  1997        PMID： 9420055      PMCID： PMC164205     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus.

Authors:  D A Regier; R C Desrosiers
Journal:  AIDS Res Hum Retroviruses       Date:  1990-11       Impact factor: 2.205

2.  In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine.

Authors:  Q Gao; Z X Gu; M A Parniak; X G Li; M A Wainberg
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

3.  Zidovudine-resistant human immunodeficiency virus selected by passage in cell culture.

Authors:  B A Larder; K E Coates; S D Kemp
Journal:  J Virol       Date:  1991-10       Impact factor: 5.103

4.  Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides.

Authors:  R F Schinazi; R M Lloyd; M H Nguyen; D L Cannon; A McMillan; N Ilksoy; C K Chu; D C Liotta; H Z Bazmi; J W Mellors
Journal:  Antimicrob Agents Chemother       Date:  1993-04       Impact factor: 5.191

5.  Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase.

Authors:  M Tisdale; S D Kemp; N R Parry; B A Larder
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205

6.  In vitro enzymatic activity of human immunodeficiency virus type 1 reverse transcriptase mutants in the highly conserved YMDD amino acid motif correlates with the infectious potential of the proviral genome.

Authors:  J K Wakefield; S A Jablonski; C D Morrow
Journal:  J Virol       Date:  1992-11       Impact factor: 5.103

7.  The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine.

Authors:  Q Gao; Z Gu; M A Parniak; J Cameron; N Cammack; C Boucher; M A Wainberg
Journal:  Antimicrob Agents Chemother       Date:  1993-06       Impact factor: 5.191

8.  High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase.

Authors:  C A Boucher; N Cammack; P Schipper; R Schuurman; P Rouse; M A Wainberg; J M Cameron
Journal:  Antimicrob Agents Chemother       Date:  1993-10       Impact factor: 5.191

9.  Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine.

Authors:  Z Gu; Q Gao; X Li; M A Parniak; M A Wainberg
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

10.  Molecular and biological characterization of simian immunodeficiency virus macaque strain 32H proviral clones containing nef size variants.

Authors:  E W Rud; M Cranage; J Yon; J Quirk; L Ogilvie; N Cook; S Webster; M Dennis; B E Clarke
Journal:  J Gen Virol       Date:  1994-03       Impact factor: 3.891
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  8 in total

Review 1.  Molecular impact of the M184V mutation in human immunodeficiency virus type 1 reverse transcriptase.

Authors:  Karidia Diallo; Matthias Götte; M A Wainberg
Journal:  Antimicrob Agents Chemother       Date:  2003-11       Impact factor: 5.191

2.  Characterization of the Drug Resistance Profiles of Integrase Strand Transfer Inhibitors in Simian Immunodeficiency Virus SIVmac239.

Authors:  Said A Hassounah; Yannan Liu; Peter K Quashie; Maureen Oliveira; Daniela Moisi; Bluma G Brenner; Paul A Sandstrom; Thibault Mesplède; Mark A Wainberg
Journal:  J Virol       Date:  2015-09-16       Impact factor: 5.103

3.  Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.

Authors:  S G Sarafianos; K Das; A D Clark; J Ding; P L Boyer; S H Hughes; E Arnold
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-31       Impact factor: 11.205

4.  Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase.

Authors:  Koen K A Van Rompay; Tim B Matthews; Joanne Higgins; Don R Canfield; Ross P Tarara; Mark A Wainberg; Raymond F Schinazi; Niels C Pedersen; Thomas W North
Journal:  J Virol       Date:  2002-06       Impact factor: 5.103

5.  Wild-type and YMDD mutant murine leukemia virus reverse transcriptases are resistant to 2',3'-dideoxy-3'-thiacytidine.

Authors:  E K Halvas; E S Svarovskaia; E O Freed; V K Pathak
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

6.  The M184V mutation in reverse transcriptase can delay reversion of attenuated variants of simian immunodeficiency virus.

Authors:  James B Whitney; Maureen Oliveira; Mervi Detorio; Yongjun Guan; Mark A Wainberg
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

7.  Reduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophage.

Authors:  Varuni K Jamburuthugoda; Jose M Santos-Velazquez; Mark Skasko; Darwin J Operario; Vandana Purohit; Pauline Chugh; Erika A Szymanski; Joseph E Wedekind; Robert A Bambara; Baek Kim
Journal:  J Biol Chem       Date:  2008-01-24       Impact factor: 5.157

8.  Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine.

Authors:  Jeffrey P Murry; Joanne Higgins; Timothy B Matthews; Victoria Y Huang; Koen K A Van Rompay; Niels C Pedersen; Thomas W North
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103
  8 in total

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