Literature DB >> 9418306

The genetic reconstruction of BCG as a new immunotherapeutic tool.

M A O'Donnell1.   

Abstract

The bacillus of Calmette and Guérin (BCG), long appreciated for its role as a live vaccine for the prevention of tuberculosis, is undergoing a rebirth as a recombinant delivery vehicle for foreign antigens and bioactive proteins. Recombinant BCG causes long-lived specific humoral and cellular immunity and may ultimately prove to be a powerful and cost-effective new weapon against both infectious pathogens and certain cancers.

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Year:  1997        PMID: 9418306     DOI: 10.1016/S0167-7799(97)01134-7

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN: 0167-7799            Impact factor:   19.536


  3 in total

1.  Molecular cloning and sequencing of the circumsporozoite protein gene from Plasmodium falciparum strain FCC-1/HN and expression of the gene in Mycobacteria.

Authors:  C Zheng; P Xie; Y Chen
Journal:  J Clin Microbiol       Date:  2001-08       Impact factor: 5.948

2.  Recombinant bacille Calmette-Guérin (BCG) expressing human interferon-alpha 2B demonstrates enhanced immunogenicity.

Authors:  Y Luo; X Chen; R Han; M A O'Donnell
Journal:  Clin Exp Immunol       Date:  2001-02       Impact factor: 4.330

Review 3.  Recombinant BCGs for tuberculosis and bladder cancer.

Authors:  Alok K Singh; Geetha Srikrishna; Trinity J Bivalacqua; William R Bishai
Journal:  Vaccine       Date:  2021-09-27       Impact factor: 3.641

  3 in total

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