Literature DB >> 9418209

Single-step synthesis of [18F]haloperidol from the chloro-precursor and its applications in PET imaging of a cat's brain.

K Hashizume1, H Tamakawa, N Hashimoto, Y Miyake.   

Abstract

We have established a convenient synthesis process for the synthesis of[18F]haloperidol using a single-step 18F-for-Cl exchange reaction and a new elution system for the preparative high performance liquid chromatography (HPLC) using C18 bonded vinylalcohol copolymer gel (ODP) and a basic eluent. We successfully applied the product to cat-PET study and got clear images of the striatum, showing the usefulness of this synthesis.

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Year:  1997        PMID： 9418209     DOI： 10.1016/s0969-8043(97)00023-7

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  2 in total

1.  NHC-Copper Mediated Ligand-Directed Radiofluorination of Aryl Halides.

Authors:  Liam S Sharninghausen; Allen F Brooks; Wade P Winton; Katarina J Makaravage; Peter J H Scott; Melanie S Sanford
Journal:  J Am Chem Soc       Date:  2020-04-10       Impact factor: 15.419

Review 2.  Allosteric Interactions between Adenosine A2A and Dopamine D2 Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging.

Authors:  Kavya Prasad; Erik F J de Vries; Philip H Elsinga; Rudi A J O Dierckx; Aren van Waarde
Journal:  Int J Mol Sci       Date:  2021-02-09       Impact factor: 5.923
  2 in total

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