Literature DB >> 941791

A method for the measurement of ultra-low amounts of prostaglandins in inflammatory exudates using gas chromatography and mass spectrometry.

B W Wilson, W Snedden, K T Tham, D A Willoughby.   

Abstract

A GC-MS assay for PGE2 and PGF2alpha has been described. The method is highly specific and sensitive down to the sub-picogram level. The assay has been used to measure the time dependence of PG concentration in carrageenan-induced inflammatory exudates and the results compared with a bioassay. Estimates of the extraction and purification yield of PGs from exudates have also been obtained.

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Year:  1976        PMID： 941791     DOI： 10.1007/bf01972204

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  1 in total

1.  The separation, identification and estimation of prostaglandins in nanogram quantities by combined gas chromatography-mass spectrometry.

Authors:  C J Thompson; M Los; E W Horton
Journal:  Life Sci I       Date:  1970-09-01
  1 in total
  2 in total

1.  Professor Derek Albert Willoughby (1930-2004).

Authors:  K D Rainsford
Journal:  Inflammopharmacology       Date:  2005       Impact factor: 4.473

2.  Determination of prostaglandin profiles in lipopolysaccharide-challenged guinea pig spleen.

Authors:  X Yao; Y Dai; A Johnson; M A Hass; C Feleder
Journal:  Biomed Chromatogr       Date:  2012-09-12       Impact factor: 1.902
  2 in total

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