Literature DB >> 9417859

The retinoblastoma protein pathway in cell cycle control and cancer.

J Bartek1, J Bartkova, J Lukas.   

Abstract

Recent discoveries in diverse fields of biomedical research have merged to reveal the molecular basis of cell cycle control and a critical role of subverting this homeostatic mechanism in cancer development. At the heart of these processes lies a late G1 checkpoint governed by the "RB pathway" whose molecular composition, functions, and cancer-associated defects are briefly evaluated in this review. This exciting new knowledge raises a plethora of conceptual issues in cell biology, with potential practical implications for biotechnology and medicine.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9417859     DOI： 10.1006/excr.1997.3776

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  41 in total

1.  The kinetic origins of the restriction point in the mammalian cell cycle.

Authors:  B D Aguda; Y Tang
Journal:  Cell Prolif       Date:  1999-10       Impact factor: 6.831

2.  Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition.

Authors:  D G Pestov; Z Strezoska; L F Lau
Journal:  Mol Cell Biol       Date:  2001-07       Impact factor: 4.272

3.  Down-regulation of phospho-non-receptor Src tyrosine kinases contributes to growth inhibition of cervical cancer cells.

Authors:  Lu Kong; Zhihong Deng; Yanzhong Zhao; Yamei Wang; Fazlul H Sarkar; Yuxiang Zhang
Journal:  Med Oncol       Date:  2010-06-08       Impact factor: 3.064

4.  Retinoblastoma tumor suppressor protein signals through inhibition of cyclin-dependent kinase 2 activity to disrupt PCNA function in S phase.

Authors:  Z Sever-Chroneos; S P Angus; A F Fribourg; H Wan; I Todorov; K E Knudsen; E S Knudsen
Journal:  Mol Cell Biol       Date:  2001-06       Impact factor: 4.272

Review 5.  Cell cycle control mechanisms in B-1 and B-2 lymphoid subsets.

Authors:  Michael J Piatelli; Debra Tanguay; Thomas L Rothstein; Thomas C Chiles
Journal:  Immunol Res       Date:  2003       Impact factor: 2.829

Review 6.  Bugs as drugs for cancer.

Authors:  Eleanor J Cheadle; Andrew M Jackson
Journal:  Immunology       Date:  2002-09       Impact factor: 7.397

7.  RB reversibly inhibits DNA replication via two temporally distinct mechanisms.

Authors:  Steven P Angus; Christopher N Mayhew; David A Solomon; Wesley A Braden; Michael P Markey; Yukiko Okuno; M Cristina Cardoso; David M Gilbert; Erik S Knudsen
Journal:  Mol Cell Biol       Date:  2004-06       Impact factor: 4.272

8.  Sodium salicylate inhibits proliferation and induces G1 cell cycle arrest in human pancreatic cancer cell lines.

Authors:  R A Perugini; T P McDade; F J Vittimberga; A J Duffy; M P Callery
Journal:  J Gastrointest Surg       Date:  2000 Jan-Feb       Impact factor: 3.452

Review 9.  The sweet side of the cell cycle.

Authors:  Ee Phie Tan; Francesca E Duncan; Chad Slawson
Journal:  Biochem Soc Trans       Date:  2017-04-15       Impact factor: 5.407

10.  Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression.

Authors:  E S Knudsen; C Buckmaster; T T Chen; J R Feramisco; J Y Wang
Journal:  Genes Dev       Date:  1998-08-01       Impact factor: 11.361
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.