Literature DB >> 9415892

Sustainable cutaneous gene delivery.

H Deng1, Q Lin, P A Khavari.   

Abstract

Durable gene delivery to human skin is necessary for lasting correction of human genetic skin disease. Current cutaneous gene-delivery strategies, however, have achieved only transient gene expression, often only within a small percentage of tissue cells. The recent inability to sustain phenotypic correction of human genetic skin disease due to loss of therapeutic gene expression in regenerated epidermal tissue has highlighted this current limitation. In an effort to surmount this problem, we have generated gene delivery vectors that produce more durable gene delivery in human skin tissue in vivo.

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Year:  1997        PMID： 9415892     DOI： 10.1038/nbt1297-1388

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


  10 in total

1.  In vivo assessment of gene delivery to keratinocytes by lentiviral vectors.

Authors:  Ulrich Kuhn; Atsushi Terunuma; Wolfgang Pfutzner; Ruth Ann Foster; Jonathan C Vogel
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

2.  Topical colchicine selection of keratinocytes transduced with the multidrug resistance gene (MDR1) can sustain and enhance transgene expression in vivo.

Authors:  W Pfutzner; A Terunuma; C L Tock; E K Snead; T M Kolodka; M M Gottesman; L Taichman; J C Vogel
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-16       Impact factor: 11.205

3.  In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa.

Authors:  P B Robbins; Q Lin; J B Goodnough; H Tian; X Chen; P A Khavari
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-10       Impact factor: 11.205

4.  Evidence for keratinocyte stem cells in vitro: long term engraftment and persistence of transgene expression from retrovirus-transduced keratinocytes.

Authors:  T M Kolodka; J A Garlick; L B Taichman
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-14       Impact factor: 11.205

5.  A deafness-associated mutant human connexin 26 improves the epithelial barrier in vitro.

Authors:  Y K Stella Man; Caroline Trolove; Daniel Tattersall; Anna C Thomas; Annie Papakonstantinopoulou; Drashnika Patel; Claire Scott; Jiehan Chong; Daniel J Jagger; Edel A O'Toole; Harshad Navsaria; Michael A Curtis; David P Kelsell
Journal:  J Membr Biol       Date:  2007-06-21       Impact factor: 1.843

6.  Long-term type VII collagen restoration to human epidermolysis bullosa skin tissue.

Authors:  Zurab Siprashvili; Ngon T Nguyen; Maria Y Bezchinsky; M Peter Marinkovich; Alfred T Lane; Paul A Khavari
Journal:  Hum Gene Ther       Date:  2010-10       Impact factor: 5.695

7.  Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface.

Authors:  G Pellegrini; O Golisano; P Paterna; A Lambiase; S Bonini; P Rama; M De Luca
Journal:  J Cell Biol       Date:  1999-05-17       Impact factor: 10.539

8.  GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis.

Authors:  E Pantazi; E Gemenetzidis; G Trigiante; G Warnes; L Shan; X Mao; M Ikram; M-T Teh; Y-J Lu; M P Philpott
Journal:  Cell Death Dis       Date:  2014-01-30       Impact factor: 8.469

9.  FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation.

Authors:  Emilios Gemenetzidis; Amrita Bose; Adeel M Riaz; Tracy Chaplin; Bryan D Young; Muhammad Ali; David Sugden; Johanna K Thurlow; Sok-Ching Cheong; Soo-Hwang Teo; Hong Wan; Ahmad Waseem; Eric K Parkinson; Farida Fortune; Muy-Teck Teh
Journal:  PLoS One       Date:  2009-03-16       Impact factor: 3.240

10.  Invasive oral cancer stem cells display resistance to ionising radiation.

Authors:  Emilios Gemenetzidis; Luke Gammon; Adrian Biddle; Helena Emich; Ian C Mackenzie
Journal:  Oncotarget       Date:  2015-12-22
  10 in total

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