Literature DB >> 9415409

Drug retention, efflux, and resistance in tumor cells.

A Krishan1, C M Fitz, I Andritsch.   

Abstract

Multiple drug resistance (MDR) in tumor cells has been related to the expression of transport proteins which alter cellular drug transport and distribution. Three different genes (mdr, MRP, and LRP) and their products have been implicated in MDR. Several fluorescent dyes have been used to monitor the effect of these transport proteins on drug retention, as well as for screening of drugs which block drug efflux and thus enhance cellular drug retention and cytotoxicity. The present review summarizes current knowledge about MDR phenotypic markers and techniques available for study of MDR by flow cytometry.

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Year:  1997        PMID： 9415409

Source DB:  PubMed          Journal:  Cytometry        ISSN： 0196-4763


  12 in total

1.  Radiation- and chemoinduced multidrug resistance in colon carcinoma cells.

Authors:  Detlef Bartkowiak; Michael Stempfhuber; Thomas Wiegel; Dirk Bottke
Journal:  Strahlenther Onkol       Date:  2009-12       Impact factor: 3.621

2.  Inhibition of multidrug resistance-associated protein (MRP) functional activity with pluronic block copolymers.

Authors:  D W Miller; E V Batrakova; A V Kabanov
Journal:  Pharm Res       Date:  1999-03       Impact factor: 4.200

3.  Fundamental relationships between the composition of pluronic block copolymers and their hypersensitization effect in MDR cancer cells.

Authors:  E Batrakova; S Lee; S Li; A Venne; V Alakhov; A Kabanov
Journal:  Pharm Res       Date:  1999-09       Impact factor: 4.200

4.  Pluronic P85 increases permeability of a broad spectrum of drugs in polarized BBMEC and Caco-2 cell monolayers.

Authors:  E V Batrakova; S Li; D W Miller; A V Kabanov
Journal:  Pharm Res       Date:  1999-09       Impact factor: 4.200

Review 5.  Polymer genomics: an insight into pharmacology and toxicology of nanomedicines.

Authors:  Alexander V Kabanov
Journal:  Adv Drug Deliv Rev       Date:  2006-10-06       Impact factor: 15.470

Review 6.  An essential relationship between ATP depletion and chemosensitizing activity of Pluronic block copolymers.

Authors:  Alexander V Kabanov; Elena V Batrakova; Valery Yu Alakhov
Journal:  J Control Release       Date:  2003-08-28       Impact factor: 9.776

7.  Ultrasound and microbubble induced release from intracellular compartments.

Authors:  Farah Hussein; Costin Antonescu; Raffi Karshafian
Journal:  BMC Biotechnol       Date:  2017-05-18       Impact factor: 2.563

8.  Cisplatin-induced expression of Gb3 enables verotoxin-1 treatment of cisplatin resistance in malignant pleural mesothelioma cells.

Authors:  D Johansson; C Andersson; J Moharer; A Johansson; P Behnam-Motlagh
Journal:  Br J Cancer       Date:  2009-12-15       Impact factor: 7.640

Review 9.  The multiple facets of drug resistance: one history, different approaches.

Authors:  Evandro Luís Niero; Bianca Rocha-Sales; Camila Lauand; Beatriz Araujo Cortez; Marcelo Medina de Souza; Paula Rezende-Teixeira; Marcel Shiniti Urabayashi; Adam Arai Martens; Jorge Henrique Neves; Gláucia Maria Machado-Santelli
Journal:  J Exp Clin Cancer Res       Date:  2014-04-28

10.  Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment.

Authors:  Dandan Wang; Xiaowei Xu; Kai Zhang; Bin Sun; Lu Wang; Lin Meng; Qilin Liu; Changyu Zheng; Bai Yang; Hongchen Sun
Journal:  Int J Nanomedicine       Date:  2017-12-28
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