Literature DB >> 9415307

Induction of antigen-specific antitumor immunity with adenovirus-transduced dendritic cells.

J Gong1, L Chen, D Chen, M Kashiwaba, Y Manome, T Tanaka, D Kufe.   

Abstract

Transduction of dendritic cells (DC) can result in presentation of tumor-associated antigens and induction of immunity against undefined epitopes. The present studies demonstrate adenovirus (Ad)-mediated transduction of the beta-galactosidase gene in mouse DC. Similar transductions have been obtained with the gene encoding the DF3/MUC1 tumor-associated antigen. We show that the Ad-transduced DC are functional in primary allogeneic mixed lymphocyte reactions. Mice immunized with Ad-transduced DC develop cytotoxic T lymphocytes that are specific for the beta-galactosidase or DF3/MUC1 antigens. The results also demonstrate that Ad MUC1-transduced DC induce a specific response which inhibits the growth of DF3/MUC1-positive tumors. These findings support the usefulness of Ad-transduced DC for in vivo immunization against tumor-associated antigens.

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Year:  1997        PMID： 9415307     DOI： 10.1038/sj.gt.3300496

Source DB:  PubMed          Journal:  Gene Ther        ISSN： 0969-7128            Impact factor:   5.250


  14 in total

1.  In vitro induction of anterior gradient-2-specific cytotoxic T lymphocytes by dendritic cells transduced with recombinant adenoviruses as a potential therapy for colorectal cancer.

Authors:  Hyun Ju Lee; Cheol Yi Hong; Mi Hyun Kim; Youn Kyung Lee; Thanh Nhan Nguyen-Pham; Byoung Chul Park; Deok Hwan Yang; Ik Joo Chung; Hyeoung Joon Kim; Je Jung Lee
Journal:  Exp Mol Med       Date:  2012-01-31       Impact factor: 8.718

2.  Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells.

Authors:  J Gong; D Chen; M Kashiwaba; Y Li; L Chen; H Takeuchi; H Qu; G J Rowse; S J Gendler; D Kufe
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-26       Impact factor: 11.205

3.  Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carcinoma cells.

Authors:  J Gong; D Avigan; D Chen; Z Wu; S Koido; M Kashiwaba; D Kufe
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-14       Impact factor: 11.205

4.  Selection and characterization of MUC1-specific CD8+ T cells from MUC1 transgenic mice immunized with dendritic-carcinoma fusion cells.

Authors:  J Gong; V Apostolopoulos; D Chen; H Chen; S Koido; S J Gendler; I F McKenzie; D Kufe
Journal:  Immunology       Date:  2000-11       Impact factor: 7.397

5.  Macrophage inflammatory protein 3alpha transgene attracts dendritic cells to established murine tumors and suppresses tumor growth.

Authors:  T Fushimi; A Kojima; M A Moore; R G Crystal
Journal:  J Clin Invest       Date:  2000-05       Impact factor: 14.808

6.  Antigen-specific polyclonal cytotoxic T lymphocytes induced by fusions of dendritic cells and tumor cells.

Authors:  Shigeo Koido; Sadamu Homma; Eiichi Hara; Yoshihisa Namiki; Toshifumi Ohkusa; Jianlin Gong; Hisao Tajiri
Journal:  J Biomed Biotechnol       Date:  2010-04-07

7.  Engineered lentivector targeting of dendritic cells for in vivo immunization.

Authors:  Lili Yang; Haiguang Yang; Kendra Rideout; Taehoon Cho; Kye Il Joo; Leslie Ziegler; Abigail Elliot; Anthony Walls; Dongzi Yu; David Baltimore; Pin Wang
Journal:  Nat Biotechnol       Date:  2008-02-24       Impact factor: 54.908

Review 8.  Advances in inducing adaptive immunity using cell-based cancer vaccines: Clinical applications in pancreatic cancer.

Authors:  Mikio Kajihara; Kazuki Takakura; Tomoya Kanai; Zensho Ito; Yoshihiro Matsumoto; Shigetaka Shimodaira; Masato Okamoto; Toshifumi Ohkusa; Shigeo Koido
Journal:  World J Gastroenterol       Date:  2016-05-14       Impact factor: 5.742

9.  Vaccination of mice with MUC1 cDNA suppresses the development of lung metastases.

Authors:  Mika Kamata; Kaori Denda-Nagai; Nobuyoshi Kubota; Satoshi Aida; Kazuyoshi Takeda; Tatsuro Irimura
Journal:  Clin Exp Metastasis       Date:  2002       Impact factor: 5.150

10.  Induction of protective and therapeutic anti-pancreatic cancer immunity using a reconstructed MUC1 DNA vaccine.

Authors:  Yefei Rong; Dayong Jin; Wenchuan Wu; Wenhui Lou; Danshong Wang; Tiantao Kuang; Xiaoling Ni; Xinyu Qin
Journal:  BMC Cancer       Date:  2009-06-18       Impact factor: 4.430
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