Literature DB >> 9415148

Application of antisense technology to therapeutics.

O Heidenreich1, S H Kang, X Xu, M Nerenberg.   

Abstract

Antisense oligonucleotides inhibit gene expression by binding in a sequence-specific manner to an RNA target. Modern nucleotide chemistry has enabled the synthesis of chemically modified oligonucleotides that are highly resistant to nuclease degradation. Among other applications, these agents are currently being evaluated as potential antiviral and anticancer drugs. However, several unsolved problems remain. Poor efficiency of delivery to cells, tissue toxicity and antisense-independent biological effects of oligonucleotides currently limit the widespread application of antisense oligonucleotides to human disease. This article reviews some of the applications of antisense oligonucleotides and discusses problems associated with these applications.

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Year:  1995        PMID： 9415148     DOI： 10.1016/s1357-4310(95)80090-5

Source DB:  PubMed          Journal:  Mol Med Today        ISSN： 1357-4310


  6 in total

1.  Inhibition of IL-6 in mice by anti-NF-kappaB oligodeoxyribonucleotide N3'-->oligodeoxyribonnucleotide N3' --> P5' phosphoramidates.

Authors:  L Wang; S Gryaznov; M Nerenberg
Journal:  Inflammation       Date:  1999-12       Impact factor: 4.092

Review 2.  In vitro and in vivo action of antisense RNA.

Authors:  W Nellen; G Sczakiel
Journal:  Mol Biotechnol       Date:  1996-08       Impact factor: 2.695

3.  RNase H-independent antisense activity of oligonucleotide N3 '--> P5 ' phosphoramidates.

Authors:  O Heidenreich; S Gryaznov; M Nerenberg
Journal:  Nucleic Acids Res       Date:  1997-02-15       Impact factor: 16.971

4.  Trafficking through the Rev/RRE pathway is essential for efficient inhibition of human immunodeficiency virus type 1 by an antisense RNA derived from the envelope gene.

Authors:  Alex M Ward; David Rekosh; Marie-Louise Hammarskjold
Journal:  J Virol       Date:  2008-10-29       Impact factor: 5.103

5.  Ligand-induced sequestering of branchpoint sequence allows conditional control of splicing.

Authors:  Dong-Suk Kim; Veronica Gusti; Kenneth J Dery; Rajesh K Gaur
Journal:  BMC Mol Biol       Date:  2008-02-12       Impact factor: 2.946

6.  Synthesis by High-Efficiency Liquid-Phase (HELP) Method of Oligonucleotides Conjugated with High-Molecular Weight Polyethylene Glycols (PEGs).

Authors:  G M Bonora; S Zaramella; F M Veronese
Journal:  Biol Proced Online       Date:  1998-05-14       Impact factor: 3.244
  6 in total

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