The distribution of angiotensin II type 1 receptors, and the tissue renin-angiotensin systems.

Since its discovery, the functions of the renin-angiotensin system (RAS) have attracted a great deal of attention, and the roles it plays under normal conditions, and in disease, acquire a deepening significance with every year. In general, the RAS has been considered largely in terms of its roles in sodium and potassium homeostasis and the regulation of blood pressure. The continued acquisition of information on the distribution of angiotensin receptors, however, emphasizes that our interpretation needs to be widened, and it is now clear that angiotensin II has an array of functions in the tissues, which are unrelated to its systemic roles. This paracrine function is brought about by the existence of complete, localized tissue RASs, which respond to physiological demand independently from the systemic system.