Literature DB >> 9414106

Characterisation of the rat and mouse homologues of gC1qBP, a 33 kDa glycoprotein that binds to the globular 'heads' of C1q.

N J Lynch1, K B Reid, R H van den Berg, M R Daha, L A Leigh, B Ghebrehiwet, W B Lim, W J Schwaeble.   

Abstract

gC1qBP is a 33 kDa glycoprotein that binds to the globular 'heads' of C1q. We have cloned cDNAs encoding the rat and mouse homologues of gC1qBP. Comparison of the cDNA-derived amino acid sequences of gC1qBP reveals that either of the rodent sequences is 89.9% identical to the reported human sequence. Recombinant rat gC1qBP binds avidly to human C1q. gC1qBP mRNA is abundantly expressed in every rat and mouse tissue analysed. Rat mesangial cells synthesise gC1qBP, but do not express gC1qBP on the cell surface. In rat serum, gC1qBP is present at low levels.

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Year:  1997        PMID： 9414106     DOI： 10.1016/s0014-5793(97)01348-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  A proteomic approach to identification of plutonium-binding proteins in mammalian cells.

Authors:  Baikuntha P Aryal; Tatjana Paunesku; Gayle E Woloschak; Chuan He; Mark P Jensen
Journal:  J Proteomics       Date:  2011-12-03       Impact factor: 4.044

2.  gC1qR expression in normal and pathologic human tissues: differential expression in tissues of epithelial and mesenchymal origin.

Authors:  Francine R Dembitzer; Yayoi Kinoshita; David Burstein; Robert G Phelps; Mary Beth Beasley; Roberto Garcia; Noam Harpaz; Shabnam Jaffer; Swan N Thung; Pamela D Unger; Berhane Ghebrehiwet; Ellinor I Peerschke
Journal:  J Histochem Cytochem       Date:  2012-06       Impact factor: 2.479

3.  The multicompartmental p32/gClqR as a new target for antibody-based tumor targeting strategies.

Authors:  David Sánchez-Martín; Angel M Cuesta; Valentina Fogal; Erkki Ruoslahti; Luis Alvarez-Vallina
Journal:  J Biol Chem       Date:  2010-12-14       Impact factor: 5.157

Review 4.  An approach to p32/gC1qR/HABP1: a multifunctional protein with an essential role in cancer.

Authors:  Carlos Alejandro Egusquiza-Alvarez; Martha Robles-Flores
Journal:  J Cancer Res Clin Oncol       Date:  2022-04-20       Impact factor: 4.322

5.  The contribution of gC1qR/p33 in infection and inflammation.

Authors:  Ellinor I B Peerschke; Berhane Ghebrehiwet
Journal:  Immunobiology       Date:  2007-01-03       Impact factor: 3.144

6.  Direct binding of hepatitis C virus core to gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck and Akt.

Authors:  Zhi Qiang Yao; Audrey Eisen-Vandervelde; Stephen N Waggoner; Evan M Cale; Young S Hahn
Journal:  J Virol       Date:  2004-06       Impact factor: 5.103

7.  C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells.

Authors:  C A Ogden; A deCathelineau; P R Hoffmann; D Bratton; B Ghebrehiwet; V A Fadok; P M Henson
Journal:  J Exp Med       Date:  2001-09-17       Impact factor: 14.307

8.  Anti gC1qR/p32/HABP1 Antibody Therapy Decreases Tumor Growth in an Orthotopic Murine Xenotransplant Model of Triple Negative Breast Cancer.

Authors:  Ellinor I Peerschke; Elisa de Stanchina; Qing Chang; Katia Manova-Todorova; Afsar Barlas; Anne G Savitt; Brian V Geisbrecht; Berhane Ghebrehiwet
Journal:  Antibodies (Basel)       Date:  2020-10-06

Review 9.  Complement C1q Binding Protein (C1QBP): Physiological Functions, Mutation-Associated Mitochondrial Cardiomyopathy and Current Disease Models.

Authors:  Jie Wang; Christopher L-H Huang; Yanmin Zhang
Journal:  Front Cardiovasc Med       Date:  2022-03-02

10.  Soluble gC1qR in Blood and Body Fluids: Examination in a Pancreatic Cancer Patient Cohort.

Authors:  Ellinor Ib Peerschke; Ricardo Jmge Brandwijk; Francine R Dembitzer; Yayoi Kinoshita; Berhane Ghebrehiwet
Journal:  Int J Cancer Res Mol Mech       Date:  2015-09-03
  10 in total

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