| Literature DB >> 9413873 |
M Okawa1, K Takahashi, K Egashira, H Furuta, Y Higashitani, T Higuchi, H Ichikawa, Y Ichimaru, Y Inoue, Y Ishizuka, N Ito, K Kamei, M Kaneko, Y Kim, M Kohsaka, T Komori, T Kotorii, M Matsumoto, K Mishima, Y Mizuki, K Morimoto, H Nagayama, T Ohta, N Okamoto, S Takahashi.
Abstract
The active form of vitamin B12 (methylcobalamin) has been reported to be effective on sleep-wake rhythm disorders. Previous studies, however, were performed under open trial, and the effect of vitamin B12 has not been properly evaluated. The aim of this double-blind study was to investigate the efficacy of methylcobalamin on delayed sleep phase syndrome (DSPS). Methylcobalamin (3 mg/day) or placebo was administered for 4 weeks. The subjects were 50 patients with DSPS aged 13-55 years (26.8 +/- 1.3), 27 of whom received the active drug while 23 received the placebo. No significant differences were observed between the 2 groups in subjective evaluations of mood or drowsiness during the daytime or in night sleep by sleep-log evaluation. These results indicate that 3 mg methylcobalamin administered over 4 weeks is not an effective treatment for DSPS.Entities:
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Year: 1997 PMID： 9413873 DOI： 10.1111/j.1440-1819.1997.tb03198.x
Source DB: PubMed Journal: Psychiatry Clin Neurosci ISSN： 1323-1316 Impact factor: 5.188