Literature DB >> 9413203

Preferential cytotoxicity to tumor cells of 3,5-diprenyl-4-hydroxycinnamic acid (artepillin C) isolated from propolis.

T Matsuno1, S K Jung, Y Matsumoto, M Saito, J Morikawa.   

Abstract

A tumoricidal substance was isolated from Brazilian propolis as guided by cytotoxicity assay on HuH 13 (human hepatocellular carcinoma) cell and was characterized to be 3-[4-hydroxy-3,5-bis (3-methyl-2-butenyl) phenyl]-2-propenoic acid (3,5-diprenyl-4-hydroxycinnamic acid (artepillin C)). It exhibited preferential cytotoxicity to tumor cells cultured in vitro. The cytotoxicity observed seemed to be partly attributable to apoptosis-like DNA fragmentation. The compound showed anti-tumor activity more effective than that of 5-fluorouracil to transplantable human tumor cell lines when tested on histoculture drug response assay system.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9413203

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  12 in total

1.  Artepillin C derived from propolis induces neurite outgrowth in PC12m3 cells via ERK and p38 MAPK pathways.

Authors:  Yoshio Kano; Noboru Horie; Shima Doi; Fumika Aramaki; Hidefumi Maeda; Fukumi Hiragami; Kenji Kawamura; Hirotoshi Motoda; Yoshihisa Koike; Junichi Akiyama; Sueo Eguchi; Ken Hashimoto
Journal:  Neurochem Res       Date:  2008-03-13       Impact factor: 3.996

2.  Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis.

Authors:  Ewelina Szliszka; Grzegorz Zydowicz; Elzbieta Mizgala; Wojciech Krol
Journal:  Int J Oncol       Date:  2012-06-25       Impact factor: 5.650

3.  Ethanol extract of chinese propolis facilitates functional recovery of locomotor activity after spinal cord injury.

Authors:  Masaki Kasai; Hidefumi Fukumitsu; Hitomi Soumiya; Shoei Furukawa
Journal:  Evid Based Complement Alternat Med       Date:  2010-09-08       Impact factor: 2.629

4.  Origin and Chemical Variation of Brazilian Propolis.

Authors:  Antonio Salatino; Erica Weinstein Teixeira; Giuseppina Negri; Dejair Message
Journal:  Evid Based Complement Alternat Med       Date:  2005-02-09       Impact factor: 2.629

5.  Plant Origin of Green Propolis: Bee Behavior, Plant Anatomy and Chemistry.

Authors:  Erica Weinstein Teixeira; Giuseppina Negri; Renata M S A Meira; Dejair Message; Antonio Salatino
Journal:  Evid Based Complement Alternat Med       Date:  2005-01-06       Impact factor: 2.629

6.  Artepillin C, a major ingredient of Brazilian propolis, induces a pungent taste by activating TRPA1 channels.

Authors:  Taketoshi Hata; Shigemi Tazawa; Shozo Ohta; Mee-Ra Rhyu; Takumi Misaka; Kenji Ichihara
Journal:  PLoS One       Date:  2012-11-02       Impact factor: 3.240

7.  Influence of propolis on hygiene, gingival condition, and oral microflora in patients with cleft lip and palate treated with fixed orthodontic appliances.

Authors:  Agnieszka Machorowska-Pieniążek; Tadeusz Morawiec; Anna Mertas; Marta Tanasiewicz; Arkadiusz Dziedzic; Wojciech Król
Journal:  Evid Based Complement Alternat Med       Date:  2013-05-19       Impact factor: 2.629

8.  Aqueous extract of brazilian green propolis: primary components, evaluation of inflammation and wound healing by using subcutaneous implanted sponges.

Authors:  Sandra Aparecida Lima de Moura; Giuseppina Negri; Antônio Salatino; Luiza Dias da Cunha Lima; Luana Pereira Antunes Dourado; Juliana Barros Mendes; Silvia Passos Andrade; Mônica Alves Neves Diniz Ferreira; Denise Carmona Cara
Journal:  Evid Based Complement Alternat Med       Date:  2011-06-08       Impact factor: 2.629

9.  Chemical Composition and Biological Activity of Extracts Obtained by Supercritical Extraction and Ethanolic Extraction of Brown, Green and Red Propolis Derived from Different Geographic Regions in Brazil.

Authors:  Bruna Aparecida Souza Machado; Rejane Pina Dantas Silva; Gabriele de Abreu Barreto; Samantha Serra Costa; Danielle Figuerêdo da Silva; Hugo Neves Brandão; José Luiz Carneiro da Rocha; Odir Antônio Dellagostin; João Antônio Pegas Henriques; Marcelo Andres Umsza-Guez; Francine Ferreira Padilha
Journal:  PLoS One       Date:  2016-01-08       Impact factor: 3.240

Review 10.  Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1β Production.

Authors:  József Tőzsér; Szilvia Benkő
Journal:  Mediators Inflamm       Date:  2016-09-08       Impact factor: 4.711
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.