BACKGROUND AND PURPOSE: Superoxide dismutase (SOD) is one of the major free radical scavenging systems that might play a role in both degenerative and acute diseases of the central nervous system. METHODS: We measured SOD activity in the serum of 41 patients with acute ischemic stroke with a chemiluminometric assay based on the generation of oxygen free radicals by xanthine and xanthine oxidase. RESULTS: SOD activity was significantly lower in patients with ischemic stroke than in age-matched control patients with nonvascular, neurological illnesses (n = 24; P < .034, Wilcoxon rank test). The activity was inversely correlated with the size of infarction on CT (P = .01, Spearman correlation) and the severity of neurological deficits (P < .001, Spearman correlation). The decreased SOD activity recovered within 5 days after stroke to values found in serum of control patients. CONCLUSIONS: Our data suggest that the SOD activity in serum is reduced in stroke patients, and replacement of antioxidative activity could be beneficial in the acute treatment of cerebral ischemia.
BACKGROUND AND PURPOSE:Superoxide dismutase (SOD) is one of the major free radical scavenging systems that might play a role in both degenerative and acute diseases of the central nervous system. METHODS: We measured SOD activity in the serum of 41 patients with acute ischemic stroke with a chemiluminometric assay based on the generation of oxygen free radicals by xanthine and xanthine oxidase. RESULTS:SOD activity was significantly lower in patients with ischemic stroke than in age-matched control patients with nonvascular, neurological illnesses (n = 24; P < .034, Wilcoxon rank test). The activity was inversely correlated with the size of infarction on CT (P = .01, Spearman correlation) and the severity of neurological deficits (P < .001, Spearman correlation). The decreased SOD activity recovered within 5 days after stroke to values found in serum of control patients. CONCLUSIONS: Our data suggest that the SOD activity in serum is reduced in strokepatients, and replacement of antioxidative activity could be beneficial in the acute treatment of cerebral ischemia.
Authors: Dalibor Paspalj; Petar Nikic; Milan Savic; Dragan Djuric; Igor Simanic; Vladimir Zivkovic; Nevena Jeremic; Ivan Srejovic; Vladimir Jakovljevic Journal: Mol Cell Biochem Date: 2015-04-28 Impact factor: 3.396
Authors: José Magalhães; António Ascensão; Franklim Marques; José M C Soares; Rita Ferreira; Maria J Neuparth; José A Duarte Journal: Eur J Appl Physiol Date: 2004-09-29 Impact factor: 3.078
Authors: Petra Kravcukova; Viera Danielisova; Miroslava Nemethova; Jozef Burda; Miroslav Gottlieb Journal: Cell Mol Neurobiol Date: 2009-03-04 Impact factor: 5.046