Literature DB >> 9409735

Expression cloning and characterization of a renal organic anion transporter from winter flounder.

N A Wolff1, A Werner, S Burkhardt, G Burckhardt.   

Abstract

The cDNA coding for a renal p-aminohippurate (PAH) transporter from winter flounder (Pseudopleuronectes americanus), designated fROAT, was cloned by functional expression in Xenopus laevis oocytes. fROAT is approximately 2.8 kbp in length and encodes a protein of 562 amino acids, related to the rat renal organic anion transporter ROAT1/OAT1 and the organic cation transporters OCT1 and OCT2. In oocytes, fROAT mediated probenecid-sensitive PAH uptake, with a Km for PAH of about 20 microM, and inhibited by external glutarate (GA) (1 mM). The functional characteristics suggest that fROAT is the basolateral PAH/dicarboxylate exchanger of the flounder kidney.

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Year:  1997        PMID： 9409735     DOI： 10.1016/s0014-5793(97)01304-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  23 in total

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Authors:  C Srimaroeng; J L Perry; J B Pritchard
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Review 5.  Trafficking and other regulatory mechanisms for organic anion transporting polypeptides and organic anion transporters that modulate cellular drug and xenobiotic influx and that are dysregulated in disease.

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Journal:  Br J Pharmacol       Date:  2017-04-24       Impact factor: 8.739

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Journal:  J Biol Chem       Date:  2010-05-06       Impact factor: 5.157

7.  Determination of the external loops and the cellular orientation of the N- and the C-termini of the human organic anion transporter hOAT1.

Authors:  Mei Hong; Kunihiko Tanaka; Zui Pan; Jianjie Ma; Guofeng You
Journal:  Biochem J       Date:  2007-01-15       Impact factor: 3.857

8.  Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin- and clathrin-dependent pathway.

Authors:  Qiang Zhang; Mei Hong; Peng Duan; Zui Pan; Jianjie Ma; Guofeng You
Journal:  J Biol Chem       Date:  2008-09-25       Impact factor: 5.157

9.  Novobiocin is a potent inhibitor for human organic anion transporters.

Authors:  Peng Duan; Guofeng You
Journal:  Drug Metab Dispos       Date:  2009-03-12       Impact factor: 3.922

Review 10.  The SLC22 drug transporter family.

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Journal:  Pflugers Arch       Date:  2003-07-19       Impact factor: 3.657
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