Literature DB >> 9409556

Increased type I procollagen mRNA in airways and pulmonary vessels after vagal denervation in rats.

T W Carver1, S K Srinathan, C R Velloff, J J Pérez Fontán.   

Abstract

To test the hypothesis that increased airway strain resulting from lung denervation initiates a fibroproliferative response in the airways, we compared the transcriptional expressions of alpha1(I)-procollagen and tropoelastin in the lungs of rats subjected to unilateral vagal denervation, unilateral vagal denervation combined with ipsilateral phrenectomy, or thoracotomy without denervation (controls). We found increases in alpha1(I)-procollagen messenger ribonucleic acids (mRNAs) in the submucosa of the airways and the adventitia of airways and pulmonary vessels of the denervated lungs in 31% of the rats subjected to unilateral denervation (with and without phrenectomy), and in none of the controls. The increased transcripts were associated with collagen deposition in the peribronchial and perivascular tissue, and occasionally with cell proliferation leading to occlusion of the airway and vascular lumina. Unilateral phrenectomy did not decrease the frequency with which production of Type I procollagen was upregulated, suggesting that the upregulation was not entirely dependent on airway strain. Tropoelastin expression was not influenced by denervation. Our results indicate that the autonomic nervous system has a previously unsuspected trophic influence on collagen synthesis in the airways and pulmonary vessels. Abolition of this influence by denervation may lead to structural changes analogous to those observed in bronchiolitis obliterans after lung transplantation.

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Year:  1997        PMID: 9409556     DOI: 10.1165/ajrcmb.17.6.2830

Source DB:  PubMed          Journal:  Am J Respir Cell Mol Biol        ISSN: 1044-1549            Impact factor:   6.914


  2 in total

1.  Cardiac autonomic function correlates with arterial stiffness in the early stage of type 1 diabetes.

Authors:  S Liatis; K Alexiadou; A Tsiakou; K Makrilakis; N Katsilambros; N Tentolouris
Journal:  Exp Diabetes Res       Date:  2011-07-24

2.  Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension.

Authors:  Keimei Yoshida; Keita Saku; Kazuhiro Kamada; Kohtaro Abe; Mariko Tanaka-Ishikawa; Takeshi Tohyama; Takuya Nishikawa; Takuya Kishi; Kenji Sunagawa; Hiroyuki Tsutsui
Journal:  JACC Basic Transl Sci       Date:  2018-11-12
  2 in total

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