Literature DB >> 9408720

Cumulating evidence from randomized trials: utilizing sequential monitoring boundaries for cumulative meta-analysis.

J M Pogue1, S Yusuf.   

Abstract

We propose the adaptation of classical monitoring boundaries for use in cumulative meta-analysis as guidelines for deciding when accumulating evidence is statistically significant and medically convincing. The interpretation of information from a randomized controlled trial is compared with that from a meta-analysis. The concept of optimal information size for a meta-analysis is developed and used to adapt monitoring boundaries to cumulative meta-analysis.

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Year:  1997        PMID： 9408720     DOI： 10.1016/s0197-2456(97)00051-2

Source DB:  PubMed          Journal:  Control Clin Trials        ISSN： 0197-2456


  118 in total

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10.  Estimating required information size by quantifying diversity in random-effects model meta-analyses.

Authors:  Jørn Wetterslev; Kristian Thorlund; Jesper Brok; Christian Gluud
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