Literature DB >> 9407951

Overexpression of phospholipase C-gamma1 in rat 3Y1 fibroblast cells leads to malignant transformation.

J S Chang1, D Y Noh, I A Park, M J Kim, H Song, S H Ryu, P G Suh.   

Abstract

Phospholipase C-gamma1 (PLC-gamma1) mediates signals from various extracellular origins to evoke cellular events such as mitogenesis. Previously, we reported that PLC-gamma1 was highly expressed in colorectal cancer and familial adenomatous polyposis, suggesting that PLC-gamma1 might be oncogenic. In this study, we have established rat 3Y1 fibroblasts that overexpress whole PLC-gamma1 and src homology 2 (SH2)-SH2-SH3 domain of PLC-gamma1. These cells showed a transformed phenotype and were tumorigenic when transplanted into nude mice. These results indicate that overexpression of PLC-gamma1 could transform rat fibroblasts, and the transformation is mediated by SH2-SH2-SH3 domain of PLC-gamma1.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9407951

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  9 in total

1.  A double point mutation in PCL-gamma1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation.

Authors:  Sang Hee Chung; Sung Kuk Kim; Jung Kuk Kim; Yong Ryoul Yang; Pann Ghill Suh; Jong Soo Chang
Journal:  Exp Mol Med       Date:  2010-03-31       Impact factor: 8.718

Review 2.  Emerging anticancer therapeutic targets and the cardiovascular system: is there cause for concern?

Authors:  Xuyang Peng; Laura Pentassuglia; Douglas B Sawyer
Journal:  Circ Res       Date:  2010-04-02       Impact factor: 17.367

3.  Downregulation of erythropoietin receptor by overexpression of phospholipase C-gamma 1 is critical for decrease on focal adhesion in transformed cells.

Authors:  Jin Ku Kang; Chang-Hyun Chang; Hyo Jung Nam; Sung-Kuk Kim; Keun Jae Ahn; Heon Seok; Sang Joon Park; Yoon Joong Kang; Young Suk Jo; Minho Shong; Ho Kim
Journal:  Cell Oncol (Dordr)       Date:  2011-01-18       Impact factor: 6.730

4.  Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling.

Authors:  Debra S Regier; Jared Higbee; Katrina M Lund; Fumio Sakane; Stephen M Prescott; Matthew K Topham
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-13       Impact factor: 11.205

5.  Phosphatidylinositol phosphates directly bind to neurofilament light chain (NF-L) for the regulation of NF-L self assembly.

Authors:  Sung-Kuk Kim; Ho Kim; Yong-Ryoul Yang; Pann-Ghill Suh; Jong-Soo Chang
Journal:  Exp Mol Med       Date:  2011-03-31       Impact factor: 8.718

6.  Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform.

Authors:  Jiyoung Y Cha; Savitri Maddileti; Natalia Mitin; T Kendall Harden; Channing J Der
Journal:  J Biol Chem       Date:  2008-12-22       Impact factor: 5.157

7.  Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism.

Authors:  M K Topham; S M Prescott
Journal:  J Cell Biol       Date:  2001-03-19       Impact factor: 10.539

Review 8.  Targeting transcription factors in cancer drug discovery.

Authors:  Partha Mitra
Journal:  Explor Target Antitumor Ther       Date:  2020-12-28

9.  Drug-induced and postnatal hypothyroidism impairs the accumulation of diacylglycerol in liver and liver cell plasma membranes.

Authors:  Oksana A Krasilnikova; Nataliya S Kavok; Nataliya A Babenko
Journal:  BMC Physiol       Date:  2002-08-16
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.