Literature DB >> 9407223

Human papillomavirus detection in high-grade squamous intraepithelial lesions. Comparison of hybrid capture assay with a polymerase chain reaction system.

I Nindl1, D M Zahm, C J Meijer, J M Walboomers, A Schneider.   

Abstract

The validity of human papillomavirus (HPV) detection using the hybrid capture assay (HCA) was compared with the polymerase chain reaction (PCR) in 38 patients with high-grade squamous intraepithelial lesions (HSILs). HCA and PCR showed 84% agreement for HPV detection. HCA missed a significant higher proportion of HSIL compared with PCR (21% vs. 5%; P = .04). Thus, the sensitivity of HCA should be increased before this test can be recommended for HSIL.

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Year:  1995        PMID： 9407223     DOI： 10.1016/0732-8893(95)00187-5

Source DB:  PubMed          Journal:  Diagn Microbiol Infect Dis        ISSN： 0732-8893            Impact factor:   2.803


  2 in total

1.  Hybrid capture II, a new sensitive test for human papillomavirus detection. Comparison with hybrid capture I and PCR results in cervical lesions.

Authors:  C Clavel; M Masure; I Putaud; K Thomas; J P Bory; R Gabriel; C Quereux; P Birembaut
Journal:  J Clin Pathol       Date:  1998-10       Impact factor: 3.411

2.  Comparative evaluation of first- and second-generation digene hybrid capture assays for detection of human papillomaviruses associated with high or intermediate risk for cervical cancer.

Authors:  M Poljak; A Brencic; K Seme; A Vince; I J Marin
Journal:  J Clin Microbiol       Date:  1999-03       Impact factor: 5.948
  2 in total

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